Adjuvants

被引：7
作者：
Carter, Darrick [1 ,2 ,3 ]
Duthie, Malcolm S. [2 ,3 ]
Reed, Steven G. [2 ,3 ]
机构：
[1] PAI Life Sci Inc, 1616 Eastlake Ave E,Suite 550, Seattle, WA 98102 USA
[2] Adjuvant Technol, IDRI, 1616 Eastlake Ave E,Suite 400, Seattle, WA 98102 USA
[3] Univ Washington, Global Hlth, 1616 Eastlake Ave E,Suite 400, Seattle, WA 98102 USA
来源：
VACCINATION STRATEGIES AGAINST HIGHLY VARIABLE PATHOGENS | 2020年 / 428卷
关键词：
MONOPHOSPHORYL-LIPID-A; HEPATITIS-B-VACCINE; TOLL-LIKE RECEPTORS; T-CELL RESPONSES; IMMUNOSTIMULATORY PHOSPHOROTHIOATE OLIGONUCLEOTIDE; TRIVALENT INFLUENZA VACCINE; DOUBLE-STRANDED-RNA; SURFACE-ANTIGEN; STRUCTURAL BASIS; DENDRITIC CELLS;
D O I：
10.1007/82_2018_112
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Developing new vaccines against emerging pathogens or pathogens where variability of antigenic sites presents a challenge, the inclusion of stimulators of the innate immune system is critical to mature the immune response in a way that allows high avidity recognition while preserving the ability to react to drifted serovars. The innate immune system is an ancient mechanism for recognition of nonself and the first line of defense against pathogen insult. By triggering innate receptors, adjuvants can boost responses to vaccines and enhance the quality and magnitude of the resulting immune response. This chapter: (1) describes the innate immune system, (2) provides examples of how adjuvants are formulated to optimize their effectiveness, and (3) presents examples of how adjuvants can improve outcomes of immunization.
引用
收藏
页码：103 / 127
页数：25
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