Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro

被引：11

作者：

Sun, Xu ^{[1
]}

Zhang, Xiao-Dong ^{[1
]}

Cheng, Gang ^{[1
]}

Hu, You-Hong ^{[1
]}

Wang, He-Yao ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2009年 / 330卷 / 1-2期

基金：

国家高技术研究发展计划(863计划);

关键词：

Hepatic stellate cells; Hsp90; inhibitor; Proliferation; Cell cycle; CHAPERONE INHIBITORS; LIVER FIBROSIS; CANCER; EXPRESSION; MECHANISMS; AGENTS; ALPHA;

D O I：

10.1007/s11010-009-0131-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hepatic stellate cells (HSCs) play an important role in the development of hepatic fibrosis. Heat shock protein 90 (Hsp90) is essential for the maturation and activity of a varied group of proteins involved in signal transduction and cell cycle regulation. In this study, we found that two Hsp90 inhibitors, VER-49009 and its analog VER-49009M, inhibited the proliferation of hepatic stellate cell line CFSC cells, and both of them induced G2 phase arrest in CFSC cells. Akt expression was decreased by the treatment of Hsp90 inhibitors in CFSC cells. Based on these findings, we propose that the inhibition of Hsp90 might be a rational approach in the prevention of liver fibrosis.

引用

页码：181 / 185

页数：5

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