Hyperpolarised 13C MRI: a new horizon for non-invasive diagnosis of aggressive breast cancer

被引：13

作者：

Abeyakoon, Oshaani ^{[1
,2
]}

Latifoltojar, Arash ^{[2
]}

Gong, Fiona ^{[2
]}

Papoutsaki, Marianthi-Vasiliki ^{[2
]}

Chowdhury, Rafat ^{[2
]}

Glaser, Matthias ^{[3
,4
]}

Jeraj, Hassan ^{[2
]}

Awais, Ramla ^{[5
]}

Holt, Christoph Er ^{[3
,4
]}

Twyman, Frazer ^{[3
,6
]}

Arstad, Erik ^{[3
,4
]}

Gadian, David G. ^{[7
]}

Atkinson, David ^{[2
]}

Comment, Arnaud ^{[8
]}

O'Callaghan, James ^{[2
]}

Smith, Lorna ^{[2
]}

Beeston, Teresita ^{[2
]}

Clemente, Joey ^{[2
]}

Patani, Neill ^{[9
,10
]}

Stein, Rob ^{[5
]}

Yuneva, Mariia ^{[10
]}

Szabadkai, Gyorgi ^{[10
]}

Halligan, Steve ^{[1
,2
]}

Punwani, Shonit ^{[1
,2
]}

机构：

[1] Univ Coll London Hosp NHS Fdn Trust, Dept Radiol, London, England

[2] UCL, Div Med, Ctr Med Imaging, London, England

[3] Univ Coll London Hosp NHS Fdn Trust, Inst Nucl Med, London, England

[4] UCL, Dept Chem, 20 Gordon St, London, England

[5] Univ Coll London Hosp NHS Fdn Trust, Dept Oncol, London, England

[6] Univ Coll London Hosp NHS Fdn Trust, Pharm Dept, London, England

[7] UCL Great Ormond St, Inst Child Hlth, London, England

[8] Gen Elect Healthcare, Chalfont St Giles HP8 4SP, England

[9] Univ Coll London Hosp NHS Fdn Trust, Dept Surg, London, England

[10] Francis Crick Inst, 1 Midland Rd, London, England

来源：

BJR CASE REPORTS | 2019年 / 5卷 / 03期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1259/bjrcr.20190026

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Hyperpolarised C-13 MRI (HP-MRI) is a novel imaging technique that allows real-time analysis of metabolic pathways in vivo. The technology to conduct HP-MRI in humans has recently become available and is starting to be clinically applied. As knowledge of molecular biology advances, it is increasingly apparent that cancer cell metabolism is related to disease outcomes, with lactate attracting specific attention. Recent reviews of breast cancer screening programs have raised concerns and increased public awareness of over treatment. The scientific community needs to shift focus from improving cancer detection alone to pursuing novel methods of distinguishing aggressive breast cancers from those which will remain indolent. HP-MRI offers the opportunity to identify aggressive tumour phenotypes and help monitor/predict therapeutic response. Here we report one of the first cases of breast cancer imaged using HP-MRI alongside correlative conventional imaging, including breast MRI.

引用

页数：5

共 7 条

[1] Dynamic Nuclear Polarization Polarizer for Sterile Use Intent [J].

Ardenkjaer-Larsen, Jan H. ;

Leach, Andrew M. ;

Clarke, Neil ;

Urbahn, John ;

Anderson, Denise ;

Skloss, Timothy W. .

NMR IN BIOMEDICINE, 2011, 24 (08) :927-932

[2] Metabolic profiles of cancer cells [J].

Griffin, JL ;

Shockcor, JP .

NATURE REVIEWS CANCER, 2004, 4 (07) :551-561

[3] Kinetics of hyperpolarized 13C1-pyruvate transport and metabolism in living human breast cancer cells [J].

Harris, Talia ;

Eliyahu, Galit ;

Frydman, Lucio ;

Degani, Hadassa .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (43) :18131-18136

[4] Lactate: A Metabolic Key Player in Cancer [J].

Hirschhaeuser, Franziska ;

Sattler, Ulrike G. A. ;

Mueller-Klieser, Wolfgang .

CANCER RESEARCH, 2011, 71 (22) :6921-6925

[5] Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44 [J].

Pinheiro, Celine ;

Reis, Rui M. ;

Ricardo, Sara ;

Longatto-Filho, Adhemar ;

Schmitt, Fernando ;

Baltazar, Fatima .

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2010,

[6] Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect [J].

Scroggins, Bradley T. ;

Matsuo, Masayuki ;

White, Ayla O. ;

Saito, Keita ;

Munasinghe, Jeeva P. ;

Sourbier, Carole ;

Yamamoto, Kazutoshi ;

Diaz, Vivian ;

Takakusagi, Yoichi ;

Ichikawa, Kazuhiro ;

Mitchell, James B. ;

Krishna, Murali C. ;

Citrin, Deborah E. .

CLINICAL CANCER RESEARCH, 2018, 24 (13) :3137-3148

[7] Cancer recurrence monitoring using hyperpolarized [1-13C]pyruyate metabolic imaging in murine breast cancer model [J].

Shin, Peter J. ;

Zhu, Zihan ;

Camarda, Roman ;

Bok, Robert A. ;

Zhou, Alicia Y. ;

Kurhanewicz, John ;

Goga, Andrei ;

Vigneron, Daniel B. .

MAGNETIC RESONANCE IMAGING, 2017, 43 :105-109

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