LC-MS/MS Method for Simultaneous Determination of Linarin and Its Metabolites in Rat Plasma and Liver Tissue Samples: Application to Pharmacokinetic and Liver Tissue Distribution Study After Oral Administration of Linarin
被引:10
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作者:
Li, Yang
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Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China
Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 301617, Peoples R ChinaTianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China
Li, Yang
[1
,2
]
Guang, Chenxi
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Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China
Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 301617, Peoples R ChinaTianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China
Guang, Chenxi
[1
,2
]
Zhao, Na
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机构:
Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China
Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 301617, Peoples R ChinaTianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China
Zhao, Na
[1
,2
]
Feng, Xinchi
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Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R ChinaTianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China
Feng, Xinchi
[1
]
Qiu, Feng
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Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China
Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 301617, Peoples R ChinaTianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China
Qiu, Feng
[1
,2
]
机构:
[1] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 301617, Peoples R China
Linarin, a flavone glycoside, is considered to be a promising natural product due to its diverse pharmacological activities. Recently, it has been brought into focus for its potential to treat liver failure. In this study, a rapid and sensitive liquid chromatography electrospray-ionization tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of linarin and its three metabolites (acacetin, apigenin, and p-hydroxy benzaldehyde) in plasma and liver tissue samples of normal rats and rats with d-galactosamine (d-GalN)-induced liver injury. After liquid-liquid extraction (LLE) with ethyl acetate, chromatographic separation of the four analytes was achieved using an ACQUITY UPLC BEH-C18 (1.7 mu m, 2.1 x 50 mm) with a mobile phase of 0.01% formic acid in methanol and 0.01% formic acid at a flow rate of 0.3 mL/min. The detection was accomplished on a tandem mass spectrometer via an electrospray ionization (ESI) source by multiple reaction monitoring (MRM) in the negative ionization mode. The method had a good linearity over the concentration range of 1.00-200 ng/mL for linarin and its metabolites. The validated method was successfully applied to the pharmacokinetic and liver tissue distribution study of linarin and its metabolites after a single oral administration of linarin (90 mg/kg) to rats.
机构:
Fudan Univ, Eye & ENT Hosp, Dept Pharm, Shanghai 200031, Peoples R ChinaFudan Univ, Eye & ENT Hosp, Dept Pharm, Shanghai 200031, Peoples R China
Gu, Jifeng
Chen, Nianzu
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Fudan Univ, Eye & ENT Hosp, Dept Pharm, Shanghai 200031, Peoples R ChinaFudan Univ, Eye & ENT Hosp, Dept Pharm, Shanghai 200031, Peoples R China
Chen, Nianzu
Ding, Guoqiang
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Fudan Univ, Eye & ENT Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shanghai 200031, Peoples R ChinaFudan Univ, Eye & ENT Hosp, Dept Pharm, Shanghai 200031, Peoples R China
Ding, Guoqiang
Zhang, Zhen
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Fudan Univ, Eye & ENT Hosp, Dept Pharm, Shanghai 200031, Peoples R ChinaFudan Univ, Eye & ENT Hosp, Dept Pharm, Shanghai 200031, Peoples R China
机构:
Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R ChinaTianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
He, Jun
Tian, Chengwang
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Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R ChinaTianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
Tian, Chengwang
Ouyang, Huizi
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Tianjin Univ Tradit Chinese Med, Affiliated Hosp 1, Tianjin 300193, Peoples R ChinaTianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
Ouyang, Huizi
Adelakun, Tiwalade A.
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Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R ChinaTianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
Adelakun, Tiwalade A.
Yu, Bin
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Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R ChinaTianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
Yu, Bin
Chang, Yanxu
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Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R ChinaTianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
Chang, Yanxu
Pan, Guixiang
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Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R ChinaTianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
Pan, Guixiang
Jiang, Linghuo
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Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R ChinaTianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
Jiang, Linghuo
Gao, Xiumei
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Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R ChinaTianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China
机构:
Second Mil Med Univ, Navy Med Univ, Hosp 900, Inst Lab Med,Joint Logist Team, 156 West Second Ring Rd, Fuzhou 350025, Fujian, Peoples R ChinaSecond Mil Med Univ, Navy Med Univ, Hosp 900, Inst Lab Med,Joint Logist Team, 156 West Second Ring Rd, Fuzhou 350025, Fujian, Peoples R China
Yi, Xunfei
Lan, Xiaopeng
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Second Mil Med Univ, Navy Med Univ, Hosp 900, Inst Lab Med,Joint Logist Team, 156 West Second Ring Rd, Fuzhou 350025, Fujian, Peoples R ChinaSecond Mil Med Univ, Navy Med Univ, Hosp 900, Inst Lab Med,Joint Logist Team, 156 West Second Ring Rd, Fuzhou 350025, Fujian, Peoples R China
机构:
Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
Peking Union Med Coll, Beijing 100193, Peoples R ChinaChinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
Wang, Geng-Nan
Pan, Rui-Le
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Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
Peking Union Med Coll, Beijing 100193, Peoples R ChinaChinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
Pan, Rui-Le
Liao, Yong-Hong
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Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
Peking Union Med Coll, Beijing 100193, Peoples R ChinaChinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
Liao, Yong-Hong
Chen, Ying
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机构:
Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
Peking Union Med Coll, Beijing 100193, Peoples R ChinaChinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
Chen, Ying
Tang, Jing-Tian
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机构:
Tsinghua Univ, Inst Med Phys & Engn, Beijing 100084, Peoples R ChinaChinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
Tang, Jing-Tian
Chang, Qi
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机构:
Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
Peking Union Med Coll, Beijing 100193, Peoples R ChinaChinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
Chang, Qi
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,
2010,
878
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