Genetic variation analysis of Chinese strains of porcine circovirus type 2

被引：204

作者：

Wang, Fang ^{[1
,2
]}

Guo, Xin ^{[1
,2
]}

Ge, Xinna ^{[1
,2
]}

Wang, Zhongtian ^{[1
,2
]}

Chen, Yanhong ^{[1
,2
]}

Cha, Zhenlin ^{[1
,2
]}

Yang, Hanchun ^{[1
,2
]}

机构：

[1] China Agr Univ, Coll Vet Med, Minist Agr, Key Lab Zoonosis, Beijing 100193, Peoples R China

[2] China Agr Univ, State Key Lab Agrobiotechnol, Beijing 100193, Peoples R China

来源：

VIRUS RESEARCH | 2009年 / 145卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Porcine circovirus type 2; Genetic variation; Phylogenetic analysis; MULTISYSTEMIC WASTING SYNDROME; PHYLOGENETIC ANALYSIS; GENOTYPE DEFINITION; CLINICAL CONDITIONS; CAPSID PROTEIN; SYNDROME PMWS; PIGS; PCV2; DISEASE; SWINE;

D O I：

10.1016/j.virusres.2009.05.015

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Forty Chinese PCV2 strains collected between 2004 and 2008 were sequenced and their genetic variations were analyzed together with nine previous PCV2 isolates. Phylogenetic analysis indicated that these Chinese PCV2 strains could be divided into four genotypes (PCV-2a, PCV-2b, PCV-2d and PCV-2e), and the genotype PCV-2c defined in Denmark was not found. PCV-2d and PCV-2e were two genotypes firstly determined in our study. Variation analysis of amino acids of capsid protein revealed that Chinese PCV2 strains clustered within PCV-2d had four amino acid marker positions and the isolates within PCV-2e had seven unique amino acid mutations. Our analysis also showed that PCV-2b became dominating in China in recent years. These data contribute to the understanding of PCV2 molecular epidemiology. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：151 / 156

页数：6

共 29 条

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