Tracking stem cells in tissue-engineered organs using magnetic nanoparticles

被引：62
作者：
Hachani, Roxanne [1 ]
Lowdell, Mark [2 ]
Birchall, Martin [3 ]
Nguyen Thi Kim Thanh [1 ]
机构：
[1] UCL, Dept Phys & Astron, London WC1E 6BT, England
[2] UCL, Sch Med, Dept Haematol, London NW3 2PF, England
[3] Royal Natl Throat Nose & Ear Hosp, UCL Ear Inst, London WC1X 8DA, England
来源：
NANOSCALE | 2013年 / 5卷 / 23期
基金：
英国医学研究理事会;
关键词：
IRON-OXIDE NANOPARTICLES; IN-VIVO TRACKING; MR-IMAGING TRACKING; CONTRAST AGENT; CHONDROGENIC DIFFERENTIATION; FACILE SYNTHESIS; PARTICLE-SIZE; INTEGRIN; BIODISTRIBUTION; FERUMOXIDES;
D O I：
10.1039/c3nr03861k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The use of human stem cells (SCs) in tissue engineering holds promise in revolutionising the treatment of numerous diseases. There is a pressing need to comprehend the distribution, movement and role of SCs once implanted onto scaffolds. Nanotechnology has provided a platform to investigate this through the development of inorganic magnetic nanoparticles (MNPs). MNPs can be used to label and track SCs by magnetic resonance imaging (MRI) since this clinically available imaging modality has high spatial resolution. In this review, we highlight recent applications of iron oxide and gadolinium based MNPs in SC labelling and MRI; and offer novel considerations for their future development.
引用
收藏
页码：11362 / 11373
页数：12
相关论文
共 126 条
[1]   Magnetic nanoparticles: preparation, physical properties, and applications in biomedicine [J].
Akbarzadeh, Abolfazl ;
Samiei, Mohamad ;
Davaran, Soodabeh .
NANOSCALE RESEARCH LETTERS, 2012, 7 :1-13
[2]   Factors affecting the clearance and biodistribution of polymeric nanoparticles [J].
Alexis, Frank ;
Pridgen, Eric ;
Molnar, Linda K. ;
Farokhzad, Omid C. .
MOLECULAR PHARMACEUTICS, 2008, 5 (04) :505-515
[3]   Silica-coated super paramagnetic iron oxide nanoparticles (SPION) as biocompatible contrast agent in biomedical photoacoustics [J].
Alwi, Rudolf ;
Telenkov, Sergey ;
Mandelis, Andreas ;
Leshuk, Timothy ;
Gu, Frank ;
Oladepo, Sulayman ;
Michaelian, Kirk .
BIOMEDICAL OPTICS EXPRESS, 2012, 3 (10) :2500-2509
[4]   Highly efficient magnetic stem cell labeling with citrate-coated superparamagnetic iron oxide nanoparticles for MRI tracking [J].
Andreas, Kristin ;
Georgieva, Radostina ;
Ladwig, Mechthild ;
Mueller, Susanne ;
Notter, Michael ;
Sittinger, Michael ;
Ringe, Jochen .
BIOMATERIALS, 2012, 33 (18) :4515-4525
[5]  
[Anonymous], INT J CELL BIOL
[6]  
[Anonymous], CONTRAST MEDIA MOL I
[7]  
[Anonymous], J APPL PHYS
[8]  
Arbab Ali Syed, 2004, Mol Imaging, V3, P24, DOI 10.1162/153535004773861697
[9]   Labeling of cells with ferumoxides-protamine sulfate complexes does not inhibit function or differentiation capacity of hematopoietic or mesenchymal stem cells [J].
Arbab, AS ;
Yocum, GT ;
Rad, AM ;
Khakoo, AY ;
Fellowes, V ;
Read, EJ ;
Frank, JA .
NMR IN BIOMEDICINE, 2005, 18 (08) :553-559
[10]   A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging [J].
Arbab, AS ;
Wilson, LB ;
Ashari, P ;
Jordan, EK ;
Lewis, BK ;
Frank, JA .
NMR IN BIOMEDICINE, 2005, 18 (06) :383-389
12345678910