Synthesis of Ursolic Acid Dipeptide Derivates with Potential Biological Activity

被引：0

作者：

Manciula, Dorin ^{[1
]}

Roba, Carmen ^{[1
]}

Oprean, Ioan ^{[2
]}

Misca-Barbu, Radu ^{[3
]}

机构：

[1] Univ Babes Bolyai, Fac Environm Sci & Engn, Cluj Napoca 400294, Romania

[2] Univ Babes Bolyai, Raluca Ripan Inst Res Chem, Cluj Napoca 400294, Romania

[3] Univ Babes Bolyai, Fac Chem & Chem Engn, Cluj Napoca 400294, Romania

来源：

REVISTA DE CHIMIE | 2013年 / 64卷 / 12期

关键词：

ursolic acid; dipeptides; biological activity; ANTIINFLAMMATORY ACTIVITY; LEAVES; KINASE;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ursolic acid is a natural compound, a pentacyclic triterpene, found in abundance in Many species of native wild flora. The experimental study was intended to extract ursolic acid from Calluna vulgaris, L. Hull, (Ericaceae) and its derivatization to obtain dipeptide compounds with potential biological activity. For this purpose, three dipeptides were used: alanyl-glycine, glycyl-leucine and leucyl-glycine. The biological activity of ursoloil-glycyl-leucine has been tested on several cancer cells lines, A2780, A431, HeLa and MCF-7.

引用

页码：1454 / 1458

页数：5

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