Copper-Catalyzed Cross-Coupling between Alkyl (Pseudo)halides and Bicyclopentyl Grignard Reagents

被引：8

作者：

Andersen, Claire ^{[1
]}

Ferey, Vincent ^{[2
]}

Daumas, Marc ^{[3
]}

Bernardelli, Patrick ^{[4
]}

Guerinot, Amandine ^{[1
]}

Cossy, Janine ^{[1
]}

机构：

[1] PSL Univ, CNRS, ESPCI Paris, Mol Macromol Chem & Mat, F-75005 Paris, France

[2] Sanofi R&D, F-34080 Montpellier, France

[3] Sanofi Chim, F-30390 Aramon, France

[4] Sanofi R&D, F-91380 Chilly Mazarin, France

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 15期

关键词：

HALIDES;

D O I：

10.1021/acs.orglett.0c02115

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of a copper-catalyzed cross-coupling between primary and secondary (pseudo)halides and bicyclopentyl Grignard reagents is reported. Highly strained bicyclopentanes can be cross-coupled with a large panel of primary alkyl mesylates and secondary alkyl iodides. The catalytic system is simple and cheap, and the reaction is general and chemoselective.

引用

页码：6021 / 6025

页数：5

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