The IGF-p53 connection in cancer

被引：13

作者：

Conover, Cheryl A. ^{[1
]}

机构：

[1] Mayo Clin, Div Endocrinol, 200 First St SW, Rochester, MN 55905 USA

来源：

GROWTH HORMONE & IGF RESEARCH | 2018年 / 39卷

关键词：

IGF; p53; Tumor suppressor; IGFBP-3; PAPP-A; GAIN-OF-FUNCTION; PROGRAMMED CELL-DEATH; FACTOR I RECEPTOR; MUTANT P53; GROWTH; APOPTOSIS; TRANSCRIPTION; DEGRADATION; ACTIVATION; EXPRESSION;

D O I：

10.1016/j.ghir.2017.11.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Healthy tissue growth depends on a well-controlled and context-appropriate balance of cellular proliferation, cell cycle arrest, and programmed cell death (apoptosis). Disturbance of this balance by activation of oncogenes, inactivation/mutation of tumor suppressor genes, or inhibition of apoptosis can promote tumorigenesis. This mini-review will focus on evidence for the contribution of insulin-like growth factor (IGF) signaling and its regulation by the transcription factor, p53, to tumor development and progression.

引用

页码：25 / 28

页数：4

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