Biologics in Chronic Urticaria

被引：10

作者：

Bulkhi, Adeeb ^{[1
,2
]}

Cooke, Andrew J. ^{[1
]}

Casale, Thomas B. ^{[1
]}

机构：

[1] Univ S Florida, Div Allergy & Immunol, Dept Internal Med, Tampa, FL USA

[2] Umm Al Qura Univ, Dept Internal Med, Coll Med, Mecca, Saudi Arabia

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2017年 / 37卷 / 01期

关键词：

Chronic urticaria; Biologics; Omalizumab; Therapy; Rituximab; TNF antagonist; Intravenous immunoglobulin therapy; DOSE INTRAVENOUS IMMUNOGLOBULIN; CHRONIC AUTOIMMUNE URTICARIA; CHRONIC IDIOPATHIC/SPONTANEOUS URTICARIA; DELAYED PRESSURE URTICARIA; ANTIIMMUNOGLOBULIN-E TREATMENT; CHRONIC IDIOPATHIC URTICARIA; REFRACTORY SOLAR URTICARIA; AFFINITY IGE RECEPTOR; QUALITY-OF-LIFE; MAST-CELL;

D O I：

10.1016/j.iac.2016.08.004

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Chronic urticaria (CU) is defined as wheals, angioedema, or both, that last more than 6 weeks. Second-generation antihistamines are considered the first-line therapy for CU. Unfortunately, many patients will fail antihistamines and require alternative therapy, including immune response modifiers or biologics. Multiple biological agents have been evaluated for use in antihistamine-refractory CU, including omalizumab, rituximab, and intravenous immunoglobulin; omalizumab is the most efficacious. Because of the success of omalizumab, multiple new biologics that are directed at the IgE pathway are under investigation. This review summarizes the relevant data regarding the efficacy of biologics in antihistamine-refractory CU.

引用

页码：95 / +

页数：19

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