Total Synthesis of Carbazole Alkaloid Murrayaquinone A

被引：4

作者：

Zhang, Kun ^{[1
]}

Xu, Hongjin ^{[1
]}

Liu, Zibo ^{[1
]}

Song, Chuanjun ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 39卷 / 04期

基金：

中国国家自然科学基金;

关键词：

murrayaquinone A; carbazole alkaloid; C-H alkenylation; total synthesis; PALLADIUM-CATALYZED SYNTHESIS; DERIVATIVES; PROGRESS;

D O I：

10.6023/cjoc201812005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Murrayaquinone A is a carbazolequinone alkaloid isolated from the root bark of Murraya euchrestifolia Hayata. It has been found to exhibit cardiotonic activity on heart muscle. Starting from the commercially available 3-acylindole, the total synthesis of Murrayaquinone A was realized in eight steps in an overall yield of 8%. The key step of our synthesis involves a palladium-catalyzed intramolecular alpha-C-H alkenylation of indole derivative to construct the carbazole A ring.

引用

页码：1142 / 1146

页数：5

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