Vitamin C and quercetin modulate DNA-damaging effect of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)

被引：27

作者：

Blasiak, J ^{[1
]}

Trzeciak, A ^{[1
]}

Gasiorowska, A ^{[1
]}

Drzewoski, J ^{[1
]}

Malecka-Panas, E ^{[1
]}

机构：

[1] Univ Lodz, Dept Mol Genet, PL-90237 Lodz, Poland

来源：

PLANT FOODS FOR HUMAN NUTRITION | 2002年 / 57卷 / 01期

关键词：

comet assay; DNA damage; lymphocytes; MNNG; quercetin; vitamin C;

D O I：

10.1023/A:1013165718960

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effects of natural compounds, vitamin C and quercetin, present in fruits and vegetables, on the DNA damaging activity of a food carcinogen N-methyl- N'-nitro- N-nitrosoguanidine (MNNG) were examined using the comet assay. Vitamin C, at a concentration of 50 muM, inhibited MNNG-induced DNA damage in human lymphocytes. Quercetin, up to a concentration of 10 muM, increased the extent of DNA damage, but at concentrations above 10 muM decreased damage below control values. Furthermore, quercetin had a strong antioxidant activity against oxidative damage evoked by H2O2 at 10 muM. The results obtained suggest that vitamin C and quercetin may have anti- or pro-oxidative properties depending on the state of the cell.

引用

页码：53 / 61

页数：9

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