pH-Responsive supramolecular vesicles assembled by water-soluble pillar[5]arene and a BODIPY photosensitizer for chemo-photodynamic dual therapy

被引：132

作者：

Meng, Lu-Bo ^{[1
,2
]}

Zhang, Wenyi ^{[3
]}

Li, Dongqi ^{[1
,2
]}

Li, Yan ^{[3
]}

Hu, Xiao-Yu ^{[1
,2
]}

Wang, Leyong ^{[1
,2
]}

Licd, Guigen ^{[4
,5
]}

机构：

[1] Nanjing Univ, Key Lab Mesoscop Chem MOE, Nanjing 210093, Jiangsu, Peoples R China

[2] Nanjing Univ, Collaborat Innovat Ctr Chem Life Sci, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China

[3] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Jiangsu Key Lab Biomat & Devices, Nanjing 210096, Jiangsu, Peoples R China

[4] Nanjing Univ, Inst Chem & BioMed Sci, Sch Chem & Chem Engn, Nanjing 210023, Jiangsu, Peoples R China

[5] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 76期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

CONTROLLABLE DRUG-RELEASE; COPOLYMER MICELLES; AMINO-ACIDS; DELIVERY; NANOPARTICLES; CANCER; DERIVATIVES; BIODISTRIBUTION; COMPLEXATION; NANOCARRIERS;

D O I：

10.1039/c5cc05785j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Supramolecular vesicles which can successfully encapsulate DOX and exhibit rapid drug release in a low-pH environment are constructed based on the host-guest interaction of water-soluble pillar[5] arene and a BODIPY derivative. They show remarkable combination of chemo- and photodynamic activities, suggesting a promising drug nanocarrier.

引用

页码：14381 / 14384

页数：4

共 48 条

[31] Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities [J].