Treatment of Elderly Patients with Colorectal Cancer

被引：73
作者：
Itatani, Yoshiro [1 ]
Kawada, Kenji [1 ]
Sakai, Yoshiharu [1 ]
机构：
[1] Kyoto Univ, Grad Sch Med, Dept Surg, Kyoto 6068507, Japan
来源：
BIOMED RESEARCH INTERNATIONAL | 2018年 / 2018卷
关键词：
III COLON-CANCER; ENDOSCOPIC SUBMUCOSAL DISSECTION; LONG-TERM OUTCOMES; MRC CLASICC TRIAL; MICROSATELLITE INSTABILITY; ADJUVANT CHEMOTHERAPY; LAPAROSCOPIC SURGERY; RISK-FACTORS; STAGE-II; SERRATED PATHWAY;
D O I：
10.1155/2018/2176056
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. As society ages, the number of elderly patients with CRC will increase. The percentage of patients with right-sided colon cancer and the incidence of microsatellite instability are higher in elderly than in younger patients with CRC. Moreover, the higher incidence of comorbid diseases in elderly patients indicates the need for less invasive treatment strategies. For example, care should be taken in performing additional surgery after endoscopic submucosal dissection for elderly patients with high-risk T1 CRC. Minimally invasive surgery, such as laparoscopic colectomy, would be preferable for elderly patients with CRC. Chemotherapy for elderly patients requires careful monitoring for adverse events. The aim of this review is to summarize the clinicopathological features of CRC in elderly patients, optical surgical strategies, including endoscopic and laparoscopic resection, and chemotherapeutic strategies, including postoperative adjuvant chemotherapy and systemic chemotherapy for unresectable CRC.
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页数：8
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