Nicotine withdrawal up-regulates c-Fos transcription in pheochromocytoma cells

被引：10
|
作者：
Ichino, N [1 ]
Ishiguro, H [1 ]
Yamada, K [1 ]
Nishii, K [1 ]
Sawada, H [1 ]
Nagatsu, T [1 ]
机构：
[1] Fujita Hlth Univ, Inst Comprehens Med Sci, Aichi 4701192, Japan
来源：
NEUROSCIENCE RESEARCH | 1999年 / 35卷 / 01期
关键词：
nicotine; nicotinic acetylcholine receptors; immediately early genes; withdrawal; PC12; cells; c-Fos; Fos-related antigen-1 (Fra-1);
D O I：
10.1016/S0168-0102(99)00069-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The influence of nicotine on the expression of Fos family proteins, which specifically formed complexes with the AP-I sequence, was assessed, mRNA for c-Fos, c-jun and jun-B were up-regulated at 0.5 h after nicotine treatment, elevated c-Fos also being apparent after withdrawal. Although nicotine failed to up-regulate the mRNA level of the fra-1 gene, the Fra-1 protein was highly expressed after both treatment and withdrawal. These results indicate that nicotine treatment may affect the transcriptional activity of many genes through c-Fos and c-Jun protein expression in neural cells, and that Fra-1 protein may make a contribution. These changes in immediately early genes (IEGs) may be associated with nicotine withdrawal symptoms. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：63 / 69
页数：7
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