Detection and quantification of 47 antibiotic residues in farmed European sea bass (Dicentrarchus labrax) using a multi-class and multi-residue UHPLC-MS/MS method

被引：4

作者：

Santos, Lucia ^{[1
]}

Rosa, Joao ^{[1
,2
]}

Freitas, Andreia ^{[3
]}

Leston, Sara ^{[1
,2
]}

Barbosa, Jorge ^{[3
]}

Ramos, Fernando ^{[1
]}

机构：

[1] Univ Coimbra, Pharm Fac, REQUIMTE LAQV, Coimbra, Portugal

[2] Univ Coimbra, Dept Life Sci, CFE, Coimbra, Portugal

[3] INIAV, IP Unidade Estrateg Invest & Serv Tecnol & Segura, Rua Lagidos, Vila Do Conde, Portugal

来源：

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT | 2019年 / 36卷 / 04期

关键词：

Antibiotics; European sea bass; multi-residue; UHPLC-MS; MS; RESOLUTION MASS-SPECTROMETRY; VETERINARY DRUG RESIDUES; SCREENING METHOD; SPARUS-AURATA; FISH TISSUE; AQUACULTURE; PERFORMANCE; RESISTANCE; MILK;

D O I：

10.1080/19440049.2019.1572229

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In the present study, a multi-class multi-residue method for the simultaneous detection and determination of antibiotics in European sea bass (Dicentrarchus labrax) was developed and validated. The method based on UHPLC-MS/MS proved to be a rapid, highly selective and sensitive tool, requiring minimum sample preparation, for screening and detection of 47 compounds from eight different classes. The validation was performed according to EU regulation 2002/657/EC, proving the method's suitability for application in routine analysis. The method was applied to the analysis of 30 samples of farmed European sea bass purchased in different supermarkets in Portugal. Antibacterial residues were detected in 6 of the 30 analysed samples, namely enrofloxacin and oxytetracycline, in concentrations ranging from 0.1 to 12 mu g kg(-1).

引用

页码：561 / 570

页数：10

共 36 条

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