Sofosbuvir-based treatment regimens: real life results of 14 409 chronic HCV genotype 4 patients in Egypt

被引:61
作者
Elsharkawy, A. [1 ]
Fouad, R. [1 ]
El Akel, W. [1 ]
El Raziky, M. [1 ]
Hassany, M. [2 ]
Shiha, G. [3 ]
Said, M. [1 ]
Motawea, I. [4 ]
El Demerdash, T. [5 ]
Seif, S. [2 ]
Gaballah, A. [6 ]
El Shazly, Y. [7 ]
Makhlouf, M. A. M. [7 ]
Waked, I. [8 ]
Abdelaziz, A. O. [1 ]
Yosry, A. [1 ]
El Serafy, M. [1 ]
Thursz, M. [9 ]
Doss, W. [1 ]
Esmat, G. [1 ]
机构
[1] Cairo Univ, Endem Med & Hepatogastroentrol Dept, Fac Med, Cairo, Egypt
[2] Natl Hepatol & Trop Med Res Inst, Dept Trop Med, Cairo, Egypt
[3] Mansoura Univ, Dept Internal Med, Fac Med, Mansoura, Egypt
[4] Menia Univ, Dept Internal Med, Fac Med, Menia, Egypt
[5] Tanta Univ, Dept Trop Med, Fac Med, Tanta, Egypt
[6] Cairo Univ, Dept Internal Med, Fac Med, Cairo, Egypt
[7] Ain Shams Univ, Dept Internal Med, Fac Med, Cairo, Egypt
[8] Menoufia Univ, Natl Liver Inst, Dept Hepatol, Menoufyia, Egypt
[9] Imperial Coll London, Dept Hepatol, London, England
关键词
TREATMENT-NAIVE PATIENTS; C VIRUS-INFECTION; HEPATITIS-C; PLUS RIBAVIRIN; PEGINTERFERON ALPHA-2A; THERAPY; BURDEN; FIBROSIS; DISEASE; IMPACT;
D O I
10.1111/apt.13923
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background Chronic hepatitis C virus infection is one of the most important health problems in Egypt. The Ministry of Health's National Treatment Programme introduced sofosbuvir-based therapy in October 2014. Aim To assess the clinical effectiveness and predictors of response to SOF-based treatment regimens, either dual therapy, with SOF/ribavirin (RBV) for 6 months or triple therapy with SOF/peg-IFN-alfa-2a/RBV for 3 months, in a cohort of patients treated in National Treatment Programme affiliated centres in Egypt. Methods Between October 2014 and end of 2014, patients who were eligible for treatment were classified according to their eligibility for interferon therapy: Group 1 (interferon eligible) were treated with triple therapy for 12 weeks and Group 2 (interferon ineligible) were treated with dual therapy for 24 weeks. Difficult to treat patients included those with F3-F4 on Metavir score, Fib-4 >3.25, albumin <= 3.5, total Bilirubin >1.2 mg/dL, INR >1.2 and platelet count <150 000 mm(3). Results Twelve weeks post-treatment data were available on 14 409 patients; 8742 in group 1 and 5667 in group 2. In group 1, the sustained virological response at week 12 (SVR12) was 94% and in group 2 the SVR12 was 78.7%. Multivariate logistic regression analysis in which treatment failure is the dependent variable was done. Male gender, being a difficult to treat patient and previous interferon therapy were significant predictors of nonresponse in both treatment groups. Conclusion Results of sofosbuvir-based therapies in Egypt achieved similar rates of SVR12 as seen in phase III efficacy studies.
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收藏
页码:681 / 687
页数:7
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