Risk factors and survival outcomes in patients with brain metastases from breast cancer

被引：34

作者：

Minisini, A. M. ^{[1
]}

Moroso, S. ^{[1
]}

Gerratana, L. ^{[1
]}

Giangreco, M. ^{[2
]}

Iacono, D. ^{[1
]}

Poletto, E. ^{[1
]}

Guardascione, M. ^{[1
]}

Fontanella, C. ^{[1
]}

Fasola, G. ^{[1
]}

Puglisi, F. ^{[1
,2
]}

机构：

[1] Univ Hosp Udine, Dept Oncol, I-33100 Udine, Italy

[2] Univ Udine, Dept Med & Biol Sci, I-33100 Udine, Italy

来源：

CLINICAL & EXPERIMENTAL METASTASIS | 2013年 / 30卷 / 08期

关键词：

Breast cancer; Brain metastases; Risk factors; Prognostic factors; Immunophenotype; CNS METASTASES; TUMOR SUBTYPE; TRASTUZUMAB; DISEASE; GENES;

D O I：

10.1007/s10585-013-9594-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Development of central nervous system (CNS) metastases in breast cancer (BC) is associated with poor prognosis. The incidence of CNS metastases in metastatic BC is reported to be about 10-16 %, but different subtypes of BC are associated with different risk of developing CNS metastases. We retrospectively analysed the risk of CNS metastases and the outcome in a cohort of 473 patients with metastatic BC. CNS metastases were diagnosed in 15.6 % of patients and median survival from diagnosis of CNS metastases was 7.53 (25th-75th 2.8-18.9) months. The risk of developing CNS metastases was higher in patients with grade 3, hormone receptor negative, HER2-positive, high Ki-67 BC. When compared to luminal A subtype, only HER2-positive BC was associated with increased risk of CNS metastases. Survival from diagnosis of CNS metastases was longer in patients with HER2-positive BC, while it was shorter in patients that did not receive any locoregional treatment, or with extra-CNS disease, or with more than 3 CNS lesions.

引用

页码：951 / 956

页数：6

共 26 条

[1] Brain metastases free survival differs between breast cancer subtypes [J].

Berghoff, A. ;

Bago-Horvath, Z. ;

De Vries, C. ;

Dubsky, P. ;

Pluschnig, U. ;

Rudas, M. ;

Rottenfusser, A. ;

Knauer, M. ;

Eiter, H. ;

Fitzal, F. ;

Dieckmann, K. ;

Mader, R. M. ;

Gnant, M. ;

Zielinski, C. C. ;

Steger, G. G. ;

Preusser, M. ;

Bartsch, R. .

BRITISH JOURNAL OF CANCER, 2012, 106 (03) :440-446

[2] Genes that mediate breast cancer metastasis to the brain [J].

Bos, Paula D. ;

Zhang, Xiang H. -F. ;

Nadal, Cristina ;

Shu, Weiping ;

Gomis, Roger R. ;

Nguyen, Don X. ;

Minn, Andy J. ;

van de Vijver, Marc J. ;

Gerald, William L. ;

Foekens, John A. ;

Massague, Joan .

NATURE, 2009, 459 (7249) :1005-U137

[3] High incidence of central nervous system involvement in patients with metastatic or locally advanced breast cancer treated with epirubicin and docetaxel [J].

Crivellari, D ;

Pagani, O ;

Veronesi, A ;

Lombardi, D ;

Nolè, F ;

Thürlimann, B ;

Hess, D ;

Borner, M ;

Bauer, J ;

Martinelli, G ;

Graffeo, R ;

Sessa, C ;

Goldhirsch, A .

ANNALS OF ONCOLOGY, 2001, 12 (03) :353-356

[4]

DISTEFANO A, 1979, CANCER-AM CANCER SOC, V44, P1913, DOI 10.1002/1097-0142(197911)44:5<1913::AID-CNCR2820440554>3.0.CO

[5]

2-D

[6] Brain metastases: epidemiology and pathophysiology [J].

Gavrilovic, IT ;

Posner, JB .

JOURNAL OF NEURO-ONCOLOGY, 2005, 75 (01) :5-14

[7] Is breast cancer survival improving? Trends in survival for patients with recurrent breast cancer diagnosed from 1974 through 2000 [J].

Giordano, SH ;

Buzdar, AU ;

Smith, TL ;

Kau, SW ;

Yang, Y ;

Hortobagyi, GN .

CANCER, 2004, 100 (01) :44-52

[8] Nomogram to Predict Subsequent Brain Metastasis in Patients With Metastatic Breast Cancer [J].

Graesslin, Olivier ;

Abdulkarim, Bassam S. ;

Coutant, Charles ;

Huguet, Florence ;

Gabos, Zsolt ;

Hsu, Limin ;

Marpeau, Olivier ;

Uzan, Serge ;

Pusztai, Lajos ;

Strom, Eric A. ;

Hortobagyi, Gabriel N. ;

Rouzier, Roman ;

Ibrahim, Nuhad K. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (12) :2032-2037

[9] Cerebral metastases in metastatic breast cancer: disease-specific risk factors and survival [J].

Heitz, F. ;

Rochon, J. ;

Harter, P. ;

Lueck, H. -J. ;

Fisseler-Eckhoff, A. ;

Barinoff, J. ;

Traut, A. ;

Lorenz-Salehi, F. ;

du Bois, A. .

ANNALS OF ONCOLOGY, 2011, 22 (07) :1571-1581

[10] Triple-negative and HER2-overexpressing breast cancers exhibit an elevated risk and an earlier occurrence of cerebral metastases [J].

Heitz, Florian ;

Harter, Philipp ;

Lueck, Hans-Joachim ;

Fissler-Eckhoff, Annette ;

Lorenz-Salehi, Fatemeh ;

Scheil-Bertram, Stefanie ;

Traut, Alexander ;

du Bois, Andreas .

EUROPEAN JOURNAL OF CANCER, 2009, 45 (16) :2792-2798

← 1 2 3 →