From a clinical observation of chronic wound microbiology to the elaboration of an anti-biofilm dressing: The PANSaBIO project strategy

被引：1

作者：

Lefebvre, E. ^{[1
]}

Lequeux, I. ^{[2
]}

Vighetto, C. ^{[1
]}

Fromantin, I. ^{[3
]}

Thebault, P. ^{[2
]}

Seyer, D. ^{[1
]}

Picard, J. ^{[4
]}

Teot, L. ^{[5
]}

Meaume, S. ^{[6
]}

Freitas, M. ^{[1
,3
]}

Neffati, S. ^{[3
]}

El Guermah, L. ^{[4
]}

Pelissier, S. ^{[3
]}

Giraudier, S. ^{[4
]}

Jouenne, T. ^{[2
]}

Garde, V. L. ^{[1
]}

机构：

[1] ERRMECe Univ Cergy Pontoise, F-95000 Cergy Pontoise, France

[2] Univ Rouen, CNRS UMR 6270, Lab Polymeres Biopolymeres Surfaces, F-76821 Mont St Aignan, France

[3] Inst Curie, F-75005 Paris, France

[4] MAIA Woundcare, F-95000 Neuville Sur Oise, France

[5] CHU Montpellier, F-34000 Montpellier, France

[6] Hop Rotschild, AP HP, F-75010 Paris, France

来源：

IRBM | 2014年 / 35卷 / 02期

关键词：

PSEUDOMONAS-AERUGINOSA; ECOLOGY; PEPTIDE;

D O I：

10.1016/j.irbm.2014.02.003

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The PANSaBIO project aims to evaluate the prevalence of biofilms on a large panel of chronic wounds (more than 100 samples) and relate its presence to the type and history of the wound and its microbiology. A large file computing all the data is under construction. Moreover, several strategies to prepare an innovative anti-biofilm dressing have been developed. On one hand, antimicrobial peptides were grafted to gelatin; the modified protein can be used to prepare an active dressing. Second, various antiseptics were entrapped in a gelatin gel. An adaptation was necessary to obtain the convenient mechanical properties of the gel. Then this preparation was turned to a dressing. A first generation of dressings efficient against biofilms of Pseudomonas aeruginosa and Staphylococus aureus is available today. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：77 / 81

页数：5

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