Solubility of rosuvastatin calcium in different neat solvents at different temperatures

被引：17
作者：
Alshora, Doaa H. [1 ]
Haq, Nazrul [2 ,3 ]
Alanazi, Fars K. [3 ]
Ibrahim, Mohamed A. [1 ]
Shakeel, Faiyaz [2 ,3 ]
机构：
[1] King Saud Univ, Coll Pharm, Dept Pharmaceut, Riyadh 11451, Saudi Arabia
[2] King Saud Univ, Coll Sci, Ctr Excellence Biotechnol Res, Riyadh 11451, Saudi Arabia
[3] King Saud Univ, Coll Pharm, Dept Pharmaceut, Riyadh 11451, Saudi Arabia
来源：
JOURNAL OF CHEMICAL THERMODYNAMICS | 2016年 / 94卷
关键词：
Correlation; Neat solvent; Rosuvastatin calcium; Solubility; MAGNESIUM-DL-ASPARTATE; DRUG-DELIVERY SYSTEM; P-TOLUIC ACID; PURE SOLVENTS; 333.15; K; GREEN SOLVENTS; WATER; BIOAVAILABILITY;
D O I：
10.1016/j.jct.2015.11.019
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
In the current research work, the solubility of rosuvastatin calcium (ROSCa) in seven different neat solvents such as water, ethanol, 1-butanol, 2-butanol, ethylene glycol (EG), isopropyl alcohol (IPA) and propane-1,2-diol (PG) was measured at five different temperatures i.e. T = (298.15 to 318.15) K and atmospheric pressure. Values of the experimental solubility of ROSCa were correlated with Apelblat and ideal models which showed good correlation and model fitting. The solubility (as mole fraction) of ROSCa was recorded highest in PG (1.89 . 10(-2) at T = 318.15 K) followed by 1-butanol (8.20 . 10(-4) at T = 318.15 K), ethanol (6.81 . 10(-4) at T = 318.15 K), IPA (5.66 . 10(-4) at T = 318.15 K), EG (5.03 . 10(-4) at T = 318.15 K), 2-butanol (1.08 . 10(-4) at T = 318.15 K) and water (1.40 . 10(-5) at T = 318.15 K). The experimental results from this research work would be helpful in the development of conventional and advanced liquid dosage forms of ROSCa. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：230 / 233
页数：4
相关论文
共 19 条
[1]  
[Anonymous], 1994, US PHARM NAT FORM US
[2]   Water soluble binary and ternary complexes of diosmin with β-cyclodextrin: Spectroscopic characterization, release studies and anti-oxidant activity [J].
Anwer, Md Khalid ;
Jamil, Shahid ;
Ansari, Mohammad Javed ;
Al-Shdefat, Ramadan ;
Ali, Bahaa E. ;
Ganaie, Majid Ahmad ;
Abdel-Kader, Maged S. ;
Shakeel, Faiyaz .
JOURNAL OF MOLECULAR LIQUIDS, 2014, 199 :35-41
[3]   Solubility of Bioactive Compound Hesperidin in Six Pure Solvents at (298.15 to 333.15) K [J].
Anwer, Md Khalid ;
Al-Shdefat, Ramadan ;
Jamil, Shahid ;
Alam, Prawez ;
Abdel-Kader, Maged S. ;
Shakeel, Faiyaz .
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2014, 59 (06) :2065-2069
[4]   Solubilities of o-acetylsalicylic, 4-aminosalicylic, 3,5-dinitrosalicylic, and p-toluic acid, and magnesium-DL-aspartate in water from T = (278 to 348) K [J].
Apelblat, A ;
Manzurola, E .
JOURNAL OF CHEMICAL THERMODYNAMICS, 1999, 31 (01) :85-91
[5]   Self nanoemulsifying drug delivery system (SNEDDS) of Rosuvastatin calcium: Design, formulation, bioavailability and pharmacokinetic evaluation [J].
Balakumar, Krishnamoorthy ;
Raghavan, Chellan Vijaya ;
Selvan, Natarajan Tamil ;
Prasad, Ranganathan Hari ;
Abdu, Siyad .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2013, 112 :337-343
[6]   Measurement and Correlation of Tadalafil Solubility in Five Pure Solvents at (298.15 to 333.15) K [J].
El-Badry, Mahmoud ;
Haq, Nazrul ;
Fetih, Gihan ;
Shakeel, Faiyaz .
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2014, 59 (03) :839-843
[7]   Self-nanoemulsifying drug-delivery system for improved oral bioavailability of rosuvastatin using natural oil antihyperlipdemic [J].
Enin, Hadel A. Abo .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2015, 41 (07) :1047-1056
[8]  
Higuchi T., 1965, ADV ANAL CHEM INSTRU, V4, P117, DOI DOI 10.1016/S0076-6879(82)87029-8
[9]   Application of Liquisolid Technology for Enhancing Solubility and Dissolution of Rosuvastatin [J].
Kamble, Pavan Ram ;
Shaikh, Karimunnisa Sameer ;
Chaudhari, Pravin Digambar .
ADVANCED PHARMACEUTICAL BULLETIN, 2014, 4 (02) :197-204
[10]   Enhancement of Human Oral Bioavailability and In Vitro Antitumor Activity of Rosuvastatin via Spray Dried Self-Nanoemulsifying Drug Delivery System [J].
Kamel, Amany O. ;
Mahmoud, Azza A. .
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2013, 9 (01) :26-39
12