The Warburg effect then and now: From cancer to inflammatory diseases

被引：419

作者：

Palsson-McDermott, Eva M. ^{[1
]}

O'Neill, Luke A. J. ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Biochem & Immunol, Dublin 2, Ireland

来源：

BIOESSAYS | 2013年 / 35卷 / 11期

关键词：

Hif-1; glycolysis; inflammation; metabolism; PKM2; TLR; Warburg effect; PYRUVATE-KINASE M2; HYPOXIA-INDUCIBLE FACTOR-1; ACTIVATED PROTEIN-KINASE; TUMOR-GROWTH; T-CELLS; DEHYDROGENASE KINASE; GLUCOSE-METABOLISM; IN-VITRO; DICHLOROACETATE; METFORMIN;

D O I：

10.1002/bies.201300084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammatory immune cells, when activated, display much the same metabolic profile as a glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation towards aerobic glycolysis, a phenomenon known as the Warburg effect. The result of this change in macrophages is to rapidly provide ATP and metabolic intermediates for the biosynthesis of immune and inflammatory proteins. In addition, a rise in certain tricarboxylic acid cycle intermediates occurs notably in citrate for lipid biosynthesis, and succinate, which activates the transcription factor Hypoxia-inducible factor. In this review we take a look at the emerging evidence for a role for the Warburg effect in the immune and inflammatory responses. The reprogramming of metabolic pathways in macrophages, dendritic cells, and T cells could have relevance in the pathogenesis of inflammatory and metabolic diseases and might provide novel therapeutic strategies.

引用

页码：965 / 973

页数：9

共 73 条

[41] Metabolism of inflammation limited by AMPK and pseudo-starvation [J].

O'Neill, Luke A. J. ;

Hardie, D. Grahame .

NATURE, 2013, 493 (7432) :346-355

[42]

O'Neill Luke A J, 2011, Biochem J, V438, pe5, DOI 10.1042/BJ20111386

[43] Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle [J].

Ojuka, EO .

PROCEEDINGS OF THE NUTRITION SOCIETY, 2004, 63 (02) :275-278

[44] HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption [J].

Papandreou, I ;

Cairns, RA ;

Fontana, L ;

Lim, AL ;

Denko, NC .

CELL METABOLISM, 2006, 3 (03) :187-197

[45] Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase [J].

Park, Chan Sun ;

Bang, Bo-Ram ;

Kwon, Hyouk-Soo ;

Moon, Keun-Ai ;

Kim, Tae-Bum ;

Lee, Ki-Young ;

Moon, Hee-Bom ;

Cho, You Sook .

BIOCHEMICAL PHARMACOLOGY, 2012, 84 (12) :1660-1670

[46] Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects [J].

Pierotti, M. A. ;

Berrino, F. ;

Gariboldi, M. ;

Melani, C. ;

Mogavero, A. ;

Negri, T. ;

Pasanisi, P. ;

Pilotti, S. .

ONCOGENE, 2013, 32 (12) :1475-1487

[47] Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase - A new mechanism of action of insulin-sensitizing drugs [J].

Pilon, G ;

Dallaire, P ;

Marette, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (20) :20767-20774

[48] Hypoxia signalling in cancer and approaches to enforce tumour regression [J].

Pouyssegur, Jacques ;

Dayan, Frederic ;

Mazure, Nathalie M. .

NATURE, 2006, 441 (7092) :437-443

[49]

RACKER E, 1972, AM SCI, V60, P56

[50] SUCCINIC ACID, A METABOLIC BY-PRODUCT OF BACTEROIDES SPECIES, INHIBITS POLYMORPHONUCLEAR LEUKOCYTE FUNCTION [J].

ROTSTEIN, OD ;

PRUETT, TL ;

FIEGEL, VD ;

NELSON, RD ;

SIMMONS, RL .

INFECTION AND IMMUNITY, 1985, 48 (02) :402-408

← 1 2 3 4 5 6 7 8 →