Transdermal microgels of gentamicin

被引：21

作者：

Nnamani, P. O. ^{[1
,3
]}

Kenechukwu, F. C. ^{[1
]}

Dibua, E. U. ^{[2
]}

Ogbonna, C. C. ^{[2
,4
,5
]}

Monemeh, U. L. ^{[1
]}

Attama, A. A. ^{[1
]}

机构：

[1] Univ Nigeria, Fac Pharmaceut Sci, Dept Pharmaceut, Drug Delivery Res Unit, Nsukka, Nigeria

[2] Univ Nigeria, Dept Microbiol, Nsukka, Enugu State, Nigeria

[3] Shivaji Univ, Dept Phys, Thin Film Phys Lab, Kolhapur 416004, Maharashtra, India

[4] Univ Camerino, Probiot Res Unit, Microbiol Lab, Sch Biosci & Biotechnol, I-62032 Camerino, MC, Italy

[5] Univ Maryland, Sch Med, Inst Human Virol, Div Epidemiol & Prevent, Baltimore, MD 21201 USA

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2013年 / 84卷 / 02期

关键词：

Gentamicin; Solid lipid microparticles; Antimicrobial action; Transdermal system; Poloxamer; 407; Polyacrylic acids; DRUG-DELIVERY; SYSTEMS; FORMULATION;

D O I：

10.1016/j.ejpb.2012.11.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Phospholipid-modified solid lipid microparticles (SLMs) of Phospholipon(R) 90G and 90H encapsulating the hydrophilic drug, gentamicin were produced and loaded into three polymeric hydrogels of Poloxamer 407 and polyacrylic acids (Carbopols(R) 971P and 974P). The SLMs were characterized by morphology and particle size, drug encapsulation efficiency, thermal properties, pH, and storage stability, whereas the microgels were evaluated for viscosity, spreadability, pH, drug content, and in vitro antimicrobial drug release against five microorganisms (Klebsiella spp., Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa). Our results generally showed Poloxamer 407 microgels of P90H and P90G as having the most desirable properties in terms of fast antibacterial activity on all tested microorganisms, in vitro diffusion-dependent permeation through rat abdominal skin, spreadability, pH, and viscosity, superior to polyacrylic acids microgels. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：345 / 354

页数：10

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