Regulation of macrophage and dendritic cell function by pathogens and through immunomodulation in the avian mucosa

被引：28
作者：
de Geus, Eveline D. [1 ]
Vervelde, Lonneke [2 ,3 ]
机构：
[1] Univ Utrecht, Fac Vet Med, Dept Immunol & Infect Dis, NL-3584 CL Utrecht, Netherlands
[2] Univ Edinburgh, Roslin Inst, Easter Bush EH25 9PS, Midlothian, Scotland
[3] Univ Edinburgh, Royal Dick Sch Vet Studies, Easter Bush EH25 9PS, Midlothian, Scotland
来源：
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2013年 / 41卷 / 03期
关键词：
Macrophages; Dendritic cells; Mucosal; Infection; Immunomodulation; INFLUENZA-A VIRUS; NITRIC-OXIDE PRODUCTION; CONTROLS PHAGOSOMAL PH; BINDING LECTIN MBL; C-TYPE LECTIN; IMMUNE-RESPONSES; RESPIRATORY-TRACT; EIMERIA-TENELLA; ANTIGEN PRESENTATION; CHICKEN MACROPHAGES;
D O I：
10.1016/j.dci.2013.03.008
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
Macrophages (MPh) and dendritic cells (DC) are members of the mononuclear phagocyte system. In chickens, markers to distinguish MPh from DC are lacking, but whether MPh and DC can be distinguished in humans and mice is under debate, despite the availability of numerous markers. Mucosal MPh and DC are strategically located to ingest foreign antigens, suggesting they can rapidly respond to invading pathogens. This review addresses our current understanding of DC and MPh function, the receptors expressed by MPh and DC involved in pathogen recognition, and the responses of DC and MPh against respiratory and intestinal pathogens in the chicken. Furthermore, potential opportunities are described to modulate MPh and DC responses to enhance disease resistance, highlighting modulation through nutraceuticals and vaccination. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：341 / 351
页数：11
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