Recycling Circuit Simulation Techniques for Mass-Action Biochemical Kinetics

被引：1
|
作者：
Toettcher, Jared E. [1 ]
Apgar, Joshua F. [2 ]
Castillo, Anya R. [3 ]
Tidor, Bruce [4 ,5 ]
White, Jacob [6 ]
机构：
[1] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA
[2] Syst Biol Grp, Boehringer Ingelheim Pharmaceut, Ridgefield, CT 06877 USA
[3] MIT, Engn Syst Div, Cambridge, MA 02139 USA
[4] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[5] MIT, Dept Biol Eng, Cambridge, MA 02139 USA
[6] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
来源：
SIMULATION AND VERIFICATION OF ELECTRONIC AND BIOLOGICAL SYSTEMS | 2011年
基金：
美国国家卫生研究院;
关键词：
SENSITIVITY-ANALYSIS; SYSTEMS BIOLOGY; OSCILLATION; MODELS;
D O I：
10.1007/978-94-007-0149-6_6
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
Many numerical techniques developed for analyzing circuits can be "recycled"-that is, they can be used to analyze mass-action kinetics (MAK) models of biological processes. But the recycling must be judicious, as the differences in behavior between typical circuits and typical MAK models can impact a numerical technique's accuracy and efficiency. In this chapter, we compare circuits and MAK models from this numerical perspective, using illustrative examples, theoretical comparisons of properties such as conservation and invariance of the non-negative orthant, as well as computational results from biological system models.
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页码：115 / +
页数：3
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