How induced pluripotent stem cells are redefining personalized medicine

被引：40

作者：

Ferreira, Leonardo M. R. ^{[1
]}

Mostajo-Radji, Mohammed A.

机构：

[1] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

来源：

GENE | 2013年 / 520卷 / 01期

关键词：

Disease modeling; Regenerative medicine; Reprogramming; Stem cells; FUNCTIONAL-PROPERTIES; HUMAN FIBROBLASTS; IPS CELLS; DIRECTED DIFFERENTIATION; HUMAN ES; MOUSE; CANCER; NEURONS; GENERATION; EXPRESSION;

D O I：

10.1016/j.gene.2013.02.037

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Since the generation of the first induced pluripotent stem (iPS) cells, the stem cell field has grown at an unparalleled pace. Today, these cells have become the major tools in the advancement of personalized medicine. Here we review the experiments that lead to their discovery as well as the latest developments in iPS cell biology. By emphasizing the current applications and limitations of induced pluripotency, we discuss how iPS cells are shaping innovation in personalized therapies. In addition, we analyze the major landmarks in direct lineage reprogramming, a potentially faster alternative to the use of iPS cells in therapy. Finally, we present the current progress in disease modeling and future directions of the treatment of genetic disorders. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：1 / 6

页数：6

共 110 条

[61] Dissecting direct reprogramming through integrative genomic analysis [J].

Mikkelsen, Tarjei S. ;

Hanna, Jacob ;

Zhang, Xiaolan ;

Ku, Manching ;

Wernig, Marius ;

Schorderet, Patrick ;

Bernstein, Bradley E. ;

Jaenisch, Rudolf ;

Lander, Eric S. ;

Meissner, Alexander .

NATURE, 2008, 454 (7200) :49-U1

[62] Functional properties of motoneurons derived from mouse embryonic stem cells [J].

Miles, GB ;

Yohn, DC ;

Wichterle, H ;

Jessell, TM ;

Rafuse, VF ;

Brownstone, RM .

JOURNAL OF NEUROSCIENCE, 2004, 24 (36) :7848-7858

[63] Induced Pluripotent Stem Cells - A Cautionary Note [J].

Mummery, Christine .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (22) :2160-2162

[64] From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus [J].

Musunuru, Kiran ;

Strong, Alanna ;

Frank-Kamenetsky, Maria ;

Lee, Noemi E. ;

Ahfeldt, Tim ;

Sachs, Katherine V. ;

Li, Xiaoyu ;

Li, Hui ;

Kuperwasser, Nicolas ;

Ruda, Vera M. ;

Pirruccello, James P. ;

Muchmore, Brian ;

Prokunina-Olsson, Ludmila ;

Hall, Jennifer L. ;

Schadt, Eric E. ;

Morales, Carlos R. ;

Lund-Katz, Sissel ;

Phillips, Michael C. ;

Wong, Jamie ;

Cantley, William ;

Racie, Timothy ;

Ejebe, Kenechi G. ;

Orho-Melander, Marju ;

Melander, Olle ;

Koteliansky, Victor ;

Fitzgerald, Kevin ;

Krauss, Ronald M. ;

Cowan, Chad A. ;

Kathiresan, Sekar ;

Rader, Daniel J. .

NATURE, 2010, 466 (7307) :714-U2

[65] Generation of germline-competent induced pluripotent stem cells [J].

Okita, Keisuke ;

Ichisaka, Tomoko ;

Yamanaka, Shinya .

NATURE, 2007, 448 (7151) :313-U1

[66] Disease-specific induced pluripotent stem cells [J].

Park, In-Hyun ;

Arora, Natasha ;

Huo, Hongguang ;

Maherali, Nimet ;

Ahfeldt, Tim ;

Shimamura, Akiko ;

Lensch, M. William ;

Cowan, Chad ;

Hochedlinger, Konrad ;

Daley, George Q. .

CELL, 2008, 134 (05) :877-886

[67] Pluripotent Stem Cells: Immune to the Immune System? [J].

Pearl, Jeremy I. ;

Kean, Leslie S. ;

Davis, Mark M. ;

Wu, Joseph C. .

SCIENCE TRANSLATIONAL MEDICINE, 2012, 4 (164)

[68] Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells [J].

Polo, Jose M. ;

Liu, Susanna ;

Figueroa, Maria Eugenia ;

Kulalert, Warakorn ;

Eminli, Sarah ;

Tan, Kah Yong ;

Apostolou, Effie ;

Stadtfeld, Matthias ;

Li, Yushan ;

Shioda, Toshi ;

Natesan, Sridaran ;

Wagers, Amy J. ;

Melnick, Ari ;

Evans, Todd ;

Hochedlinger, Konrad .

NATURE BIOTECHNOLOGY, 2010, 28 (08) :848-U130

[69] Cell fusion for reprogramming pluripotency - Toward elimination of the pluripotent genome [J].

Pralong, Daniele ;

Trounson, Alan O. ;

Verma, Paul J. .

STEM CELL REVIEWS, 2006, 2 (04) :331-340

[70] In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes [J].

Qian, Li ;

Huang, Yu ;

Spencer, C. Ian ;

Foley, Amy ;

Vedantham, Vasanth ;

Liu, Lei ;

Conway, Simon J. ;

Fu, Ji-dong ;

Srivastava, Deepak .

NATURE, 2012, 485 (7400) :593-+

← 2 3 4 5 6 7 8 9 10 11 →