Successful treatment with tocilizumab in a case of Cogan's syndrome complicated with aortitis

被引：31

作者：

Shibuya, Mihoko ^{[1
]}

Fujio, Keishi ^{[1
]}

Morita, Kaoru ^{[1
]}

Harada, Hiroaki ^{[1
]}

Kanda, Hiroko ^{[1
]}

Yamamoto, Kazuhiko ^{[1
]}

机构：

[1] Univ Tokyo, Dept Allergy & Rheumatol, Grad Sch Med, Bunkyo Ku, Tokyo 1138655, Japan

来源：

MODERN RHEUMATOLOGY | 2013年 / 23卷 / 03期

关键词：

Cogan's syndrome; Aortitis; Tocilizumab; IL-6; QUALITY-OF-LIFE; GIANT-CELL ARTERITIS; DISEASE-ACTIVITY; RHEUMATOID-ARTHRITIS; TAKAYASUS-ARTERITIS; RECEPTOR INHIBITION; EMISSION-TOMOGRAPHY; CONTROLLED-TRIAL; HEARING-LOSS; FOLLOW-UP;

D O I：

10.1007/s10165-012-0691-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 69-year-old man with sensorineural hearing loss and iritis was diagnosed with atypical Cogan's syndrome. He had several systematic manifestations: aortitis, meningitis, panniculitis and seronegative arthritis. Remission induced by treatment with high doses of prednisolone was followed by relapse within 1 year. Although his condition was resistant to various immunosuppressive drugs, including methotrexate, cyclosporine, azathioprine and adalimumab, his symptoms, inflammatory response and quality of life measures were successfully improved by tocilizumab, a humanized anti-interleukin-6 receptor antibody.

引用

页码：577 / 581

页数：5

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