Correlation of visual hallucinations with occipital rCBF changes by donepezil in DLB

被引：58

作者：

Mori, T

Ikeda, M ^{[1
]}

Fukuhara, R

Nestor, PJ

Tanabe, H

机构：

[1] Ehime Univ, Sch Med, Dept Neuropsychiat, Toon City, Ehime 7910295, Japan

[2] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England

来源：

NEUROLOGY | 2006年 / 66卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1212/01.wnl.0000203114.03976.b0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors explored the neural substrate of visual hallucinations in dementia with Lewy bodies (DLB) by investigating changes in regional cerebral blood flow (rCBF) and psychiatric symptoms, before and after cholinesterase inhibitor treatment. Twenty subjects with DLB were treated with donepezil for a 12-week period. Hallucinations attenuated while receiving therapy, whereas occipital rCBF focally increased, suggesting that functional visual association cortex deficits may cause visual hallucinations in patients with DLB.

引用

页码：935 / 937

页数：3

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