North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

被引：21

作者：

Eussen, Simone J. P. M. ^{[1
,2
,3
]}

Nilsen, Roy M. ^{[4
]}

Midttun, Oivind ^{[5
]}

Hustad, Steinar ^{[3
]}

IJssennagger, Noortje ^{[6
]}

Meyer, Klaus ^{[5
]}

Fredriksen, Ase ^{[5
]}

Ulvik, Arve ^{[5
]}

Ueland, Per M. ^{[3
,7
]}

Brennan, Paul ^{[8
]}

Johansson, Mattias ^{[8
]}

Bueno-de-Mesquita, Bas ^{[9
,10
]}

Vineis, Paolo ^{[11
]}

Chuang, Shu-Chun ^{[11
]}

Boutron-Ruault, Marie Christine ^{[12
,13
]}

Dossus, Laure ^{[12
,13
]}

Perquier, Florence ^{[12
,13
]}

Overvad, Kim ^{[14
]}

Teucher, Birgit ^{[15
]}

Grote, Verena A. ^{[15
]}

Trichopoulou, Antonia ^{[16
,17
]}

Adarakis, George ^{[17
]}

Plada, Maria ^{[17
]}

Sieri, Sabina ^{[18
]}

Tumino, Rosario ^{[19
,20
]}

Santucci de Magistris, Maria ^{[21
]}

Ros, Martine M. ^{[9
,22
]}

Peeters, Petra H. M. ^{[11
,23
]}

Luisa Redondo, Maria ^{[24
]}

Zamora-Ros, Raul ^{[25
]}

Chirlaque, Maria-Dolores ^{[26
,27
]}

Ardanaz, Eva ^{[28
]}

Sonestedt, Emily ^{[29
]}

Ericson, Ulrika ^{[29
]}

Schneede, Joern ^{[30
]}

van Guelpen, Bethany ^{[31
]}

Wark, Petra A. ^{[11
]}

Gallo, Valentina ^{[11
,32
]}

Norat, Teresa ^{[11
]}

Riboli, Elio ^{[11
]}

Vollset, Stein Emil ^{[1
,2
]}

机构：

[1] Univ Bergen, Fac Dent & Med, Inst Med, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway

[2] Univ Bergen, Fac Dent & Med, Inst Med, Pharmacol Sect, Bergen, Norway

[3] Univ Bergen, Pharmacol Sect, Inst Med, Bergen, Norway

[4] Haukeland Hosp, Clin Res Ctr, N-5021 Bergen, Norway

[5] Bevital AS, Bergen, Norway

[6] Wageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands

[7] Haukeland Hosp, Lab Clin Biochem, N-5021 Bergen, Norway

[8] Int Agcy Res Canc, F-69372 Lyon, France

[9] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[10] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[11] Univ London Imperial Coll Sci Technol & Med, Fac Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[12] Inst Gustave Roussy, INSERM, U1018, Ctr Res Epidemiol & Populat Hlth, F-94805 Villejuif, France

[13] Paris South Univ, UMRS 1018, F-94805 Villejuif, France

[14] Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, Aarhus, Denmark

[15] German Canc Res Ctr, Heidelberg, Germany

[16] Univ Athens, Sch Med, WHO Collaborating Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[17] Hellen Hlth Fdn, Athens, Greece

[18] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy

[19] Civile MP Arezzo Hosp, ASP, Canc Registry, Ragusa, Italy

[20] Civile MP Arezzo Hosp, ASP, Histopathol Unit, Ragusa, Italy

[21] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[22] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostat & HTA, NL-6525 ED Nijmegen, Netherlands

[23] Univ Med Ctr, Julius Ctr, Utrecht, Netherlands

[24] Publ Hlth Directorate, Asturias, Spain

[25] Catalan Inst Oncol ICO IDIBELL, Unit Nutr Environm & Canc, Canc Epidemiol Res Programme, Barcelona, Spain

[26] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[27] CIBER Epidemiol & Salud Publ CIBERESP, Consortium Biomed Res Epidemiol & Publ Hlth, Granada, Spain

[28] Navarre Publ Hlth Inst, Pamplona, Spain

[29] Lund Univ, Dept Clin Sci, Lund, Sweden

[30] Umea Univ, Dept Pharmacol & Clin Neurosci, Umea, Sweden

[31] Umea Univ, Dept Med Biosci, Umea, Sweden

[32] London Sch Hyg & Trop Med, London WC1, England

来源：

BRITISH JOURNAL OF NUTRITION | 2013年 / 110卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

B-vitamins; Amino acids; One-carbon metabolism; Europe; COLORECTAL-CANCER; MICROBIOLOGICAL ASSAY; ALCOHOL-CONSUMPTION; TOTAL HOMOCYSTEINE; DIETARY PATTERNS; NUTRIENT INTAKE; DAIRY-PRODUCTS; FOLATE INTAKE; 10; COUNTRIES; ELDERLY-MEN;

D O I：

10.1017/S0007114512004990

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Different lifestyle patterns across Europe may influence plasma concentrations of B-vitamins and one-carbon metabolites and their relation to chronic disease. Comparison of published data on one-carbon metabolites in Western European regions is difficult due to differences in sampling procedures and analytical methods between studies. The present study aimed, to compare plasma concentrations of one-carbon metabolites in Western European regions with one laboratory performing all biochemical analyses. We performed the present study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort among 5446 presumptively healthy individuals. Quantile regression was used to compare sex-specific median concentrations between Northern (Denmark and Sweden), Central (France, Germany, The Netherlands and United Kingdom) and Southern (Greece, Spain and Italy) European regions. The lowest folate concentrations were observed in Northern Europe (men, 10.4 nmol/l; women, 10.7 nmol/l) and highest concentrations in Central Europe. Cobalamin concentrations were slightly higher in Northern Europe (men, 330 pmol/l; women, 352 pmol/l) compared with Central and Southern Europe, but did not show a clear north-south gradient. Vitamin B-2 concentrations were highest in Northern Europe (men, 22.2 nmol/l; women, 26.0 nmol/l) and decreased towards Southern Europe (P-trend < 0.001). Vitamin B-6 concentrations were highest in Central Europe in men (77.3 nmol/l) and highest in the North among women (70.4 nmol/l), with decreasing concentrations towards Southern Europe in women (P-trend < 0.001). In men, concentrations of serine, glycine and sarcosine increased from the north to south. In women, sarcosine increased from Northern to Southern Europe. These findings may provide relevant information for the study of regional differences of chronic disease incidence in association with lifestyle.

引用

页码：363 / 374

页数：12

共 60 条

[1] Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment:: A randomized placebo-controlled study
Bor, MV
Refsum, H
Bisp, MR
Bleie, O
Schneede, J
Nordrehaug, JE
Ueland, PM
Nygard, OK
Nexo, E
[J]. CLINICAL CHEMISTRY, 2003, 49 (01) : 155 - 161
[2] Botto LD, 2000, AM J EPIDEMIOL, V151, P862
[3] Coburn S P, 1996, Adv Food Nutr Res, V40, P107, DOI 10.1016/S1043-4526(08)60023-6
[4] Folate intake in Europe: recommended, actual and desired intake
deBree, A
vanDusseldorp, M
Brouwer, IA
vanhetHof, KH
SteegersTheunissen, RPM
[J]. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 1997, 51 (10) : 643 - 660
[5] DEGROOT LCPGM, 1992, NUTR REV, V50, P185, DOI 10.1111/j.1753-4887.1992.tb01323.x
[6] Dietary intake and status of folate and vitamin B12 and their association with homocysteine and cardiovascular disease in European populations
Dhonukshe-Rutten, R. A. M.
de Vries, J. H. M.
de Bree, A.
van der Put, N.
van Staveren, W. A.
de Groot, L. C. P. G. M.
[J]. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2009, 63 (01) : 18 - 30
[7] European Commission, 2006, DISC PAP SETT MAX MI
[8] Current perspectives on the cellular uptake and trafficking of riboflavin
Foraker, AB
Khantwal, CM
Swaan, PW
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2003, 55 (11) : 1467 - 1483
[9] Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism
Fredriksen, Ase
Meyer, Klaus
Ueland, Per Magne
Vollset, Stein Emil
Grotmol, Tom
Schneede, Jorn
[J]. HUMAN MUTATION, 2007, 28 (09) : 856 - 865
[10] Region-Specific Nutrient Intake Patterns Exhibit a Geographical Gradient within and between European Countries
Freisling, Heinz
Fahey, Michael T.
Moska, Aurelie
Ocke, Marga C.
Ferrari, Pietro
Jenab, Mazda
Norat, Teresa
Naska, Androniki
Welch, Ailsa A.
Navarro, Carmen
Schulz, Mandy
Wirfaelt, Elisabet
Casagrande, Corinne
Amiano, Pilar
Ardanaz, Eva
Parr, Christine
Engeset, Dagrun
Grioni, Sara
Sera, Francesco
Bueno-de-Mesquita, Bas
van der Schouw, Yvonne T.
Touvier, Mathilde
Boutron-Ruault, Marie-Christine
Halkjaer, Jytte
Dahm, Christina C.
Khaw, Kay-Tee
Crowe, Francesca
Linseisen, Jakob
Kroeger, Janine
Huybrechts, Inge
Deharveng, Genevieve
Manjer, Jonas
Agren, Asa
Trichopoulou, Antonia
Tsiotas, Kostas
Riboli, Elio
Bingham, Sheila
Slimani, Nadia
[J]. JOURNAL OF NUTRITION, 2010, 140 (07) : 1280 - 1286

← 1 2 3 4 5 6 →