Noncontact measurement of elasticity for the detection of soft-tissue tumors using phase-sensitive optical coherence tomography combined with a focused air-puff system

被引：89

作者：

Wang, Shang ^{[1
]}

Li, Jiasong ^{[1
]}

Manapuram, Ravi Kiran ^{[2
]}

Menodiado, Floredes M. ^{[1
]}

Ingram, Davis R. ^{[3
]}

Twa, Michael D. ^{[4
]}

Lazar, Alexander J. ^{[3
]}

Lev, Dina C. ^{[3
]}

Pollock, Raphael E. ^{[3
]}

Larin, Kirill V. ^{[1
,2
,5
]}

机构：

[1] Univ Houston, Dept Biomed Engn, Houston, TX 77204 USA

[2] Univ Houston, Dept Mech Engn, Houston, TX 77204 USA

[3] Univ Texas MD Anderson Canc Ctr, Sarcoma Res Ctr, Houston, TX 77030 USA

[4] Univ Houston, Coll Optometry, Houston, TX 77204 USA

[5] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA

来源：

OPTICS LETTERS | 2012年 / 37卷 / 24期

关键词：

BREAST-CANCER; ELASTOGRAPHY; MODULUS; SAMPLES; VIVO;

D O I：

10.1364/OL.37.005184

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We report on an optical noncontact method for the detection of soft-tissue tumors based on the measurement of their elasticity. A focused air-puff system is used to excite surface waves (SWs) on soft tissues with transient static pressure. A high-speed phase-sensitive optical coherence tomography system is used to measure the SWs as they propagate from the point of excitation. To evaluate the stiffness of soft tissues, the Young's modulus is quantified based on the group velocity of SWs. Pilot experiments were performed on ex vivo human myxoma and normal fat. Results demonstrate the feasibility of the proposed method to measure elasticity and differentiate soft-tissue tumors from normal tissues. (C) 2012 Optical Society of America

引用

页码：5184 / 5186

页数：3

共 5 条

[1] Combining a focused air-puff system with phase-sensitive optical coherence tomography for the detection of soft-tissue tumors based on elasticity measurement
Wang, Shang
Li, Jiasong
Vantipalli, Srilatha
Manapuram, Ravi Kiran
Ingram, Davis R.
Twa, Michael D.
Lazar, Alexander J.
Lev, Dina C.
Pollock, Raphael E.
Larin, Kirill V.
OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XVII, 2013, 8571
[2] A focused air-pulse system for optical-coherence-tomography-based measurements of tissue elasticity
Wang, Shang
Larin, K. V.
Li, Jiasong
Vantipalli, S.
Manapuram, R. K.
Aglyamov, S.
Emelianov, S.
Twa, M. D.
LASER PHYSICS LETTERS, 2013, 10 (07)
[3] Elasticity Imaging of Speckle-free Tissue Regions with Moving Acoustic Radiation Force and Phase-sensitive Optical Coherence Tomography
Hsieh, Bao-Yu
Song, Shaozhen
Thu-Mai Nguyen
Yoon, Soon Joon
Shen, Tueng
Wang, Ruikang
O'Donnell, Matthew
OPTICAL ELASTOGRAPHY AND TISSUE BIOMECHANICS III, 2016, 9710
[4] Tracking mechanical wave propagation within tissue using phase-sensitive optical coherence tomography: motion artifact and its compensation
Song, Shaozhen
Huang, Zhihong
Wang, Ruikang K.
JOURNAL OF BIOMEDICAL OPTICS, 2013, 18 (12)
[5] Measuring pulse-induced natural relative motions within human ocular tissue in vivo using phase-sensitive optical coherence tomography
O'Hara, Keith E.
Schmoll, Tilman
Vass, Clemens
Leitgeb, Rainer A.
JOURNAL OF BIOMEDICAL OPTICS, 2013, 18 (12)

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