[1] Univ Gothenburg, Inst Med, Sahlgrenska Acad, Gothenburg, Sweden
[2] Univ Cattolica Sacro Cuore, Rome, Italy
[3] Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden
[4] AstraZeneca Gothenburg, Global Med Dev, Molndal, Sweden
[5] AstraZeneca Gothenburg, IMED Biotech Unit, CVMD Translat Med Unit, Early Clin Dev, Molndal, Sweden
[6] Univ Gothenburg, Inst Hlth & Care Sci, Sahlgrenska Acad, Gothenburg, Sweden
[7] Natl Inst Hlth & Welf, Helsinki, Finland