Long-term incidence of serious fall-related injuries after bariatric surgery in Swedish obese subjects

被引:17
作者
Carlsson, Lena M. S. [1 ]
Sjoholm, Kajsa [1 ]
Ahlin, Sofie [1 ,2 ]
Jacobson, Peter [1 ]
Andersson-Assarsson, Johanna C. [1 ]
Lindahl, Linda Karlsson [1 ]
Maglio, Cristina [1 ,3 ]
Karlsson, Cecilia [1 ,4 ]
Hjorth, Stephan [1 ]
Taube, Magdalena [1 ]
Carlsson, Bjorn [1 ,5 ]
Svensson, Per-Arne [1 ,6 ]
Peltonen, Markku [7 ]
机构
[1] Univ Gothenburg, Inst Med, Sahlgrenska Acad, Gothenburg, Sweden
[2] Univ Cattolica Sacro Cuore, Rome, Italy
[3] Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden
[4] AstraZeneca Gothenburg, Global Med Dev, Molndal, Sweden
[5] AstraZeneca Gothenburg, IMED Biotech Unit, CVMD Translat Med Unit, Early Clin Dev, Molndal, Sweden
[6] Univ Gothenburg, Inst Hlth & Care Sci, Sahlgrenska Acad, Gothenburg, Sweden
[7] Natl Inst Hlth & Welf, Helsinki, Finland
基金
瑞典研究理事会; 美国国家卫生研究院;
关键词
Y GASTRIC BYPASS; RISK-FACTORS; SUICIDE; ALCOHOL; ADULTS; LIFE;
D O I
10.1038/s41366-018-0097-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Obesity increases risk of falling, but the effect of bariatric surgery on fall-related injuries is unknown. The aim of this study was therefore to study the association between bariatric surgery and long-term incidence of fall-related injuries in the prospective, controlled Swedish Obese Subjects study. At inclusion, body mass index was >= 34 kg/m(2) in men and >= 38 kg/m(2) in women. The surgery per-protocol group (n = 2007) underwent gastric bypass (n = 266), banding (n = 376), or vertical banded gastroplasty (n = 1365), and controls (n = 2040) received usual care. At the time of analysis (31 December 2013), median follow-up was 19 years (maximal 26 years). Fall-related injuries requiring hospital treatment were captured using data from the Swedish National Patient Register. During follow-up, there were 617 first-time fall-related injuries in the surgery group and 513 in the control group (adjusted hazard ratio 1.21, 95% CI, 1.07-1.36; P = 0.002). The incidence differed between treatment groups (P < 0.001, log-rank test) and was higher after gastric bypass than after usual care, banding and vertical banded gastroplasty (adjusted hazard ratio 0.50-0.52, P < 0.001 for all three comparisons). In conclusion, gastric bypass surgery was associated with increased risk of serious fall-related injury requiring hospital treatment.
引用
收藏
页码:933 / 937
页数:5
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