Macrophage Heterogeneity of Culprit Coronary Plaques in Patients With Acute Myocardial Infarction or Stable Angina

被引：28

作者：

Lee, Cheol Whan ^{[1
]}

Hwang, Ilseon ^{[4
]}

Park, Chan-Sik ^{[2
]}

Lee, Hyangsin ^{[3
]}

Park, Duk-Woo ^{[1
]}

Kang, Soo-Jin ^{[1
]}

Lee, Seung-Whan ^{[1
]}

Kim, Young-Hak ^{[1
]}

Park, Seong-Wook ^{[1
]}

Park, Seung-Jung ^{[1
]}

机构：

[1] Univ Ulsan, Asan Med Ctr, Dept Med, Seoul 138736, South Korea

[2] Univ Ulsan, Asan Med Ctr, Dept Pathol, Seoul 138736, South Korea

[3] Univ Ulsan, Asan Inst Life Sci, Seoul 138736, South Korea

[4] Keimyung Univ, Sch Med, Dept Pathol, Taegu, South Korea

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2013年 / 139卷 / 03期

关键词：

Coronary disease; Macrophage heterogeneity; Vulnerable plague; ADIPOSE-TISSUE; ATHEROSCLEROSIS; POLARIZATION; INFLAMMATION;

D O I：

10.1309/AJCP7KEYGN3OBGQX

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We investigated the polarization states of macrophages in coronary atherectomy tissues retrieved from patients with acute myocardial infarction (AMI, n = 52) or stable angina pectoris (SAP, n = 22). The specimens were analyzed immunohistochemically using antibodies specific to CD11c (M1 marker), CD206 (M2 marker), and to markers of endothelial cells, macrophages, and smooth muscle cells. Baseline characteristics were similar in the 2 groups. The proportion of areas immunopositive for alpha smooth muscle actin was similar, but those positive for CD31 and CD68 were larger in the AMI group compared with the SAP group. In addition, AMI had significantly greater areas immunopositive for CD11c (P = .007) than did SAP, but CD206 (P = .102) positivity was not different in the 2 groups. In conclusion, M1 macrophage infiltration, not M2 macrophage infiltration, was increased in culprit plaques of patients with AM. Macrophage heterogeneity may therefore be related to plaque instability.

引用

页码：317 / 322

页数：6

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