Highly water-soluble BODIPY-based fluorescent probes for sensitive fluorescent sensing of zinc(II)

被引：85

作者：

Zhu, Shilei ^{[1
]}

Zhang, Jingtuo ^{[1
]}

Janjanam, Jagadeesh ^{[1
]}

Vegesna, Giri ^{[1
]}

Luo, Fen-Tair ^{[2
]}

Tiwari, Ashutosh ^{[1
]}

Liu, Haiying ^{[1
]}

机构：

[1] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA

[2] Acad Sinica, Inst Chem, Taipei 11529, Taiwan

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2013年 / 1卷 / 12期

基金：

美国国家科学基金会;

关键词：

SYNAPTICALLY RELEASED ZN2+; MOBILE ZINC; SENSORS; ZN(II); CELLS; TRANSLOCATION; HOMEOSTASIS; NEURONS; DISEASE; COMPLEX;

D O I：

10.1039/c3tb00249g

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A zinc(II) chelator bis(pyridin-2-ylmethyl)amine moiety has been incorporated into three different highly water-soluble dyes, 2-formyl-BODIPY, 2,6-diformyl BODIPY, and 2,6-diformyl-1,7-distyryl-BODIPY, at 2-position and 2,6-positions, resulting in three highly water-soluble BODIPY-based fluorescent probes A, B and C for zinc(II) ions. Fluorescent probes A and B display sensitive fluorescent responses with significant fluorescence enhancement to zinc(II) ions at pH 7.0 while fluorescent probe C shows two distinct measurable fluorescent signals at 521 nm and 661 nm, and displays ratiometric responses to zinc(II) ions with fluorescence quenching at 661 nm and fluorescence enhancement at 521 nm. These three fluorescent probes exhibit excellent sensitive and selective responses to zinc(II) ions. Intracellular zinc(II) concentration could be monitored in cancer cells with fluorescent probe C.

引用

页码：1722 / 1728

页数：7

共 42 条

[1] Measuring picomolar intracellular exchangeable zinc in PC-12 cells using a ratiometric fluorescence biosensor [J].

Bozym, Rebecca A. ;

Thompson, Richard B. ;

Stoddard, Andrea K. ;

Fierke, Carol A. .

ACS CHEMICAL BIOLOGY, 2006, 1 (02) :103-111

[2] Understanding Zinc Quantification with Existing and Advanced Ditopic Fluorescent Zinpyr Sensors [J].

Buccella, Daniela ;

Horowitz, Joshua A. ;

Lippard, Stephen J. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (11) :4101-4114

[3] Visualizing metal ions in cells: An overview of analytical techniques, approaches, and probes [J].

Dean, Kevin M. ;

Qin, Yan ;

Palmer, Amy E. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2012, 1823 (09) :1406-1415

[4] Genetically Encoded Sensors to Elucidate Spatial Distribution of Cellular Zinc [J].

Dittmer, Philip J. ;

Miranda, Jose G. ;

Gorski, Jessica A. ;

Palmer, Amy E. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (24) :16289-16297

[5] A Highly Selective Turn-On Colorimetric, Red Fluorescent Sensor for Detecting Mobile Zinc in Living Cells [J].

Du, Pingwu ;

Lippard, Stephen J. .

INORGANIC CHEMISTRY, 2010, 49 (23) :10753-10755

[6] Transition metal speciation in the cell: Insights from the chemistry of metal ion receptors [J].

Finney, LA ;

O'Halloran, TV .

SCIENCE, 2003, 300 (5621) :931-936

[7] CYTOARCHITECTONIC DISTRIBUTION OF ZINC IN THE HIPPOCAMPUS OF MAN AND THE RAT [J].

FREDERICKSON, CJ ;

KLITENICK, MA ;

MANTON, WI ;

KIRKPATRICK, JB .

BRAIN RESEARCH, 1983, 273 (02) :335-339

[8] The neurobiology of zinc in health and disease [J].

Frederickson, CJ ;

Koh, JY ;

Bush, AI .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (06) :449-462

[9] Efficient Fluorescence Resonance Energy Transfer-Based Ratiometric Fluorescent Cellular Imaging Probe for Zn2+ Using a Rhodamine Spirolactam as a Trigger [J].

Han, Zhi-Xiang ;

Zhang, Xiao-Bing ;

Zhuo Li ;

Gong, Yi-Jun ;

Wu, Xiang-Yang ;

Zhen Jin ;

He, Chun-Mei ;

Jian, Li-Xin ;

Jing Zhang ;

Shen, Guo-Li ;

Yu, Ru-Qin .

ANALYTICAL CHEMISTRY, 2010, 82 (08) :3108-3113

[10] TRANSITION-METAL CHELATOR TPEN COUNTERACTS PHORBOL ESTER-INDUCED ACTIN CYTOSKELETAL DISRUPTION IN C6 RAT GLIOMA-CELLS WITHOUT INHIBITING ACTIVATION OR TRANSLOCATION OF PROTEIN-KINASE-C [J].

HEDBERG, KK ;

BIRRELL, GB ;

MOBLEY, PL ;

GRIFFITH, OH .

JOURNAL OF CELLULAR PHYSIOLOGY, 1994, 158 (02) :337-346

← 1 2 3 4 5 →