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Testosterone exerts selective anti-inflammatory effects on human skin mast cells in a cell subset dependent manner
被引:20
|作者:
Guhl, Sven
[1
]
Artuc, Metin
[1
]
Zuberbier, Torsten
[1
]
Babina, Magda
[1
]
机构:
[1] Charite, Dept Dermatol & Allergy, D-13353 Berlin, Germany
关键词:
androgen receptor;
cytokines;
interleukin-6;
mast cells;
testosterone;
INHIBITION;
PROFILE;
IL-6;
D O I:
10.1111/exd.12006
中图分类号:
R75 [皮肤病学与性病学];
学科分类号:
100206 ;
摘要:
Androgens are known to exert anti-inflammatory effects but their impact on mast cells (MCs) remains to be determined. Here, we show that MCs isolated from human foreskin samples (male) and those from breast skin (female) express the androgen receptor, albeit with a 10-fold difference between the subsets. While fundamental MC properties (FceRI, c-Kit, tryptase; histamine release upon FceRI cross-linking) were unaffected or slightly reduced (chymase) by testosterone, the hormone had a more profound impact on the production of cytokines, with IL-6 being a target (reduction by 53%). Interestingly, this effect was limited to breast skin MCs (15 of 16 donors displayed this phenomenon), but was not reproduced by foreskin MCs. Collectively, effector functions of human skin MCs are modulated by androgens in a gene-selective and MC subset-specific fashion. Possibly, MCs from women are more susceptible to testosterone. We also demonstrate that MC IL-6 production is highly variable among individuals.
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页码:878 / 880
页数:4
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