B-type Natriuretic Peptides in Acute Coronary Syndromes: Implications in an Aging Population

被引：9

作者：

Krim, Selim R. ^{[1
]}

Vivo, Rey P. ^{[2
,3
]}

de Lemos, James A. ^{[4
]}

机构：

[1] Ochsner Clin Fdn, John Ochsner Heart & Vasc Inst, Div Cardiol, New Orleans, LA 70121 USA

[2] Univ Texas Med Branch, Div Cardiol, Galveston, TX USA

[3] Methodist Debakey Heart & Vasc Ctr, Houston, TX USA

[4] Univ Texas SW Med Ctr Dallas, Donald W Reynolds Cardiovasc Clin Res Ctr, Dallas, TX 75390 USA

来源：

CLINICAL CARDIOLOGY | 2012年 / 35卷 / 11期

关键词：

ACUTE MYOCARDIAL-INFARCTION; CHRONIC KIDNEY-DISEASE; PROGNOSTIC VALUE; ARTERY-DISEASE; OLDER-ADULTS; MORTALITY; HEART; IMPACT; ANEMIA; ASSOCIATION;

D O I：

10.1002/clc.22035

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

B-type natriuretic peptide (BNP) and N-terminal-proBNP (NT-proBNP) are increasingly recognized as prognostic markers in patients with acute coronary syndrome (ACS). The need for novel and more effective tools for risk assessment cannot be more emphasized than in older patients with ACS given their atypical presentation, multiple comorbidities, and higher risk for mortality and morbidity. Accurate interpretation of B-type NP values in older patients with ACS, however, may be confounded by several aging-related physiologic changes. Advanced age, reduction in body mass, and kidney function and anemia have been associated with higher BNP and NT-proBNP concentrations, and may create challenges with interpreting NP levels in the elderly. This review highlights the need to better understand the physiology of BNP and NT-proBNP in older individuals and their prognostic value in older patients with ACS.

引用

页码：682 / 685

页数：4

共 31 条

[1] Acute coronary care in the elderly, Part I Non-ST-segment-elevation acute coronary syndromes - A scientific statement for healthcare professionals from the American Heart Association council on clinical cardiology - In collaboration with the society of geriatric cardiology [J].

Alexander, Karen P. ;

Newby, Kristin ;

Cannon, Christopher P. ;

Armstrong, Paul W. ;

Gibler, W. Brian ;

Rich, Michael W. ;

Van de Werf, Frans ;

White, Harvey D. ;

Weaver, W. Douglas ;

Naylor, Mary D. ;

Gore, Joel M. ;

Krumholz, Harlan M. ;

Ohman, E. Magnus .

CIRCULATION, 2007, 115 (19) :2549-2569

[2] In-Hospital Outcomes of Very Elderly Patients (85 years and Older) Undergoing Percutaneous Coronary Intervention [J].

Appleby, Clare E. ;

Ivanov, Joan ;

Mackie, Karen ;

Dzavik, Vladimir ;

Overgaard, Christopher B. .

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2011, 77 (05) :634-641

[3] Correlation and prognostic utility of B-type natriuretic peptide and its amino-terminal fragment in patients with chronic kidney disease [J].

Austin, Wendy J. ;

Bhalla, Vikas ;

Hernandez-Arce, Israel ;

Isakson, Susan R. ;

Beede, Jennifer ;

Clopton, Paul ;

Maisel, Alan S. ;

Fitzgerald, Robert L. .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2006, 126 (04) :506-512

[4] Associations among androgpens, estrogems, and natriuretic peptides in young women - Observations from the Dallas Heart Study [J].

Chang, Alice Y. ;

Abdullah, Shuaib M. ;

Jain, Tulika ;

Stanek, Harold G. ;

Das, Sandeep R. ;

McGuire, Darren K. ;

Auchus, Richard J. ;

de Lemos, James A. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (01) :109-116

[5] Prevalence of chronic kidney disease in the United States [J].

Coresh, Josef ;

Selvin, Elizabeth ;

Stevens, Lesley A. ;

Manzi, Jane ;

Kusek, John W. ;

Eggers, Paul ;

Van Lente, Frederick ;

Levey, Andrew S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 298 (17) :2038-2047

[6] Minimally elevated cardiac troponin T and elevated N-terminal pro-B-type natriuretic peptide predict mortality in older adults - Results from the Rancho Bernardo Study [J].

Daniels, Lori B. ;

Laughlin, Gail A. ;

Clopton, Paul ;

Maisel, Alan S. ;

Barrett-Connor, Elizabeth .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 52 (06) :450-459

[7] Impact of body mass and body composition on circulating levels of natriuretic peptides - Results from the Dallas heart study [J].

Das, SR ;

Drazner, MH ;

Dries, DL ;

Vega, GL ;

Stanek, HG ;

Abdullah, SM ;

Canham, RM ;

Chung, AK ;

Leonard, D ;

Wians, FH ;

de Lemos, JA .

CIRCULATION, 2005, 112 (14) :2163-2168

[8] The prognostic value of B-type natriuretic peptide in patients with acute coronary syndromes [J].

de Lemos, JA ;

Morrow, DA ;

Bentley, JH ;

Omland, T ;

Sabatine, MS ;

McCabe, CH ;

Hall, C ;

Cannon, CP ;

Braunwald, E .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (14) :1014-1021

[9] Association between anaemia and N-terminal pro-B-type natriuretic peptide (NT-proBNP): Findings from the Heart and Soul Study [J].

Desai, Arati S. ;

Bibbins-Domingo, Kirsten ;

Shlipak, Michael G. ;

Wu, Alan H. B. ;

Ali, Sadia ;

Whooley, Mary A. .

EUROPEAN JOURNAL OF HEART FAILURE, 2007, 9 (09) :886-891

[10]

Drewniak W, 2008, KARDIOL POL, V66, P750

← 1 2 3 4 →