Role of Src family kinase in the rewarding effect and hyperlocomotion induced by morphine

被引：8

作者：

Narita, M ^{[1
]}

Kato, H ^{[1
]}

Kasukawa, A ^{[1
]}

Narita, M ^{[1
]}

Suzuki, M ^{[1
]}

Takeuchi, T ^{[1
]}

Suzuki, T ^{[1
]}

机构：

[1] Hoshi Univ, Sch Pharm & Pharmacal Sci, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, Japan

来源：

NEUROREPORT | 2006年 / 17卷 / 02期

关键词：

morphine; mouse; nucleus accumbens; rewarding effect; Src family kinase;

D O I：

10.1097/01.wnr.0000198950.92820.c7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of the present study was to investigate the effect of a selective Src family kinase inhibitor, 4-amino-5-(4-chlorophenyl)(t-butyl)pyrazolo[3,4-D]pyrimidine (PP2), on the rewarding effect and hyperlocomotion induced by morphine. An intracerebroventricular pretreatment with PP2 (0.1-10nmol/mouse) significantly suppressed the morphine-induced rewarding effect and hyperlocomotion in a dose-dependent manner. We also investigated the changes in immunoreactivities to phosphorylated-Src family kinase in the nucleus accumbens of mice showing the morphine-induced rewarding effect. We found for the first time that Src family kinase is activated in the nucleus accumbens of mice showing the morphine-induced rewarding effect as compared with that found in saline-treated control mice. These findings suggest that Src family kinases in the nucleus accumbens are involved in the rewarding effect and hyperloconnotion induced by morphine.

引用

页码：115 / 119

页数：5

共 21 条

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