Design, synthesis, and antitumor activity of new bis-aminomethylnaphthalenes

被引：17

作者：

Bollini, Mariela ^{[1
]}

Jose Casal, Juan ^{[1
]}

Maria Bruno, Ana ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Organ, RA-1113 Buenos Aires, DF, Argentina

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 17期

关键词：

bis-aminomethylnaphthalenes; synthesis; antitumor activity; DNA binding;

D O I：

10.1016/j.bmc.2008.07.069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new series of bis-aminomethylnaphthalenes were synthesized in satisfactory overall yield, through a simple synthetic strategy using reductive amination. The DNA binding properties of these compounds have been examined and compared to those of reference drugs using an UV spectroscopy method. The compounds were evaluated for their in vitro anticancer activity and some of them were studied in vivo. Compound 15 exhibited remarkable antitumor activity and represents a novel template for anticancer chemotherapy and can serve as a new lead compound. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：8003 / 8010

页数：8

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