"Physiological" renal regenerating medicine in VLBW preterm infants: could a dream come true?

被引：26

作者：

Fanni, Daniela ^{[1
]}

Gerosa, Clara ^{[1
]}

Nemolato, Sonia ^{[1
]}

Mocci, Cristina ^{[1
]}

Pichiri, Giuseppina ^{[1
]}

Coni, Pierpaolo ^{[1
]}

Congiu, Terenzio ^{[2
]}

Piludu, Marco ^{[3
]}

Piras, Monica ^{[3
]}

Fraschini, Matteo ^{[4
]}

Zaffanello, Marco ^{[5
]}

Iacovidou, Nicoletta ^{[6
]}

Van Eyken, Peter ^{[7
]}

Monga, Guido ^{[8
]}

Faa, Gavino ^{[1
]}

Fanos, Vassilios ^{[9
,10
]}

机构：

[1] Univ Cagliari, Dept Pathol, Cagliari, Italy

[2] Univ Inusubria, Dept Surg & Morphol Sci, Varese, Italy

[3] Univ Cagliari, Dept Biomed, Cagliari, Italy

[4] Univ Cagliari, Dept Elect & Elect Engn, Cagliari, Italy

[5] Univ Verona, Dept Pediat, I-37100 Verona, Italy

[6] Univ Athens, Sch Med, Aretaie Hosp, Dept Obstet & Gynecol 2, Athens 11528, Greece

[7] Katholieke Univ Leuven, Dept Pathol, Louvain, Belgium

[8] Univ Piemonte Orientale, Dept Pathol, Novara, Italy

[9] Univ Cagliari, NICU, Dept Pediat & Clin Med, Inst Puericulture, Cagliari, Italy

[10] Univ Cagliari, Neonatal Sect, Cagliari, Italy

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2012年 / 25卷

关键词：

Hypertension; kidney; nephrogenesis; renal disease; DEVELOPING HUMAN KIDNEY; NEPHRON NUMBER; BLOOD-PRESSURE; GLOMERULAR NUMBER; BIRTH-WEIGHT; ADULT HYPERTENSION; GESTATIONAL-AGE; RISK-FACTORS; DISEASE; GROWTH;

D O I：

10.3109/14767058.2012.712339

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

An emerging hypothesis from the recent literature explain how specific adverse factors related with growth retardation as well as of low birth weight (LBW) might influence renal development during fetal life and then the insurgence of hypertension and renal disease in adulthood. In this article, after introducing a brief overview of human nephrogenesis, the most important factors influencing nephron number at birth will be reviewed, focusing on the "in utero" experiences that lead to an increased risk of developing hypertension and/or kidney disease in adult. Since nephrogenesis in preterm human newborns does not stop at birth, but it continues for 4-6 weeks postnatally, a better knowledge of the mechanisms able to accelerate nephrogenesis in the perinatal period, could represent a powerful tool in the hands of neonatologists. We suggest to define this approach to a possible therapy of a deficient nephrogenesis at birth "physiological renal regenerating medicine". Our goal in preterm infants, especially VLBW, could be to prolong the nephrogenesis not only for 6 weeks after birth but until 36 weeks of post conceptual age, allowing newborn kidneys to restore their nephron endowment, escaping susceptibility to hypertension and to renal disease later in life.

引用

页码：41 / 48

页数：8

共 51 条

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