Estimation of Superoxide Dismutase and Glutathione Peroxidase in Oral Submucous Fibrosis, Oral Leukoplakia and Oral Cancer - A Comparative Study

被引：34
作者：
Gurudath, Shubha [1 ]
Ganapathy, K. S. [1 ]
Sujatha, D. [1 ]
Pai, Anuradha [1 ]
Ballal, Sushmini [1 ]
Asha, M. L.
机构：
[1] Oxford Dent Coll Hosp & Res Ctr, Oxford, England
来源：
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2012年 / 13卷 / 09期
关键词：
Oral submucous fibrosis; oral leukoplakia; oral cancer; superoxide dismutase; glutathione peroxidase; ANTIOXIDANT ENZYMES; LIPID-PEROXIDATION; OXIDANT;
D O I：
10.7314/APJCP.2012.13.9.4409
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Present study was undertaken to estimate and compare erythrocyte superoxide dismutase (E-SOD) and Glutathione peroxidase (GPx) levels in oral submucous fibrosis, oral leukoplakia and oral cancer patients and age/sex matched healthy subjects, 25 in each group. Statistically significant (P<0.001) decrease in E-SOD and GPx levels were observed in OSF, oral leukoplakia and oral cancer groups as compared to the control group. Oral leukoplakia group showed lower levels in comparison with OSF (P>0.05). Oral cancer group had the lowest levels amongst the study groups. Imbalance in antioxidant enzyme status may be considered as one of the factors responsible for the pathogenesis of cancer and may serve as a potential biomarker and therapeutic target to reduce the malignant transformation in oral premalignant lesions/conditions.
引用
收藏
页码：4409 / 4412
页数：4
相关论文
共 18 条
  • [1] Baskar AA, 2004, CELL MOL BIOL LETT, V9, P665
  • [2] Epstein Joel, BURKETTS ORAL MED, V7, P170
  • [3] Fiaschi A I, 2005, Eur Rev Med Pharmacol Sci, V9, P361
  • [4] Oxidant-antioxidant status in blood and tumor tissue of oral squamous cell carcinoma patients
    Gokul, S.
    Patil, V. S.
    Jailkhani, R.
    Hallikeri, K.
    Kattappagari, K. K.
    [J]. ORAL DISEASES, 2010, 16 (01) : 29 - 33
  • [5] Role of oxidative stress and antioxidants in aetiopathogenesis and management of oral submucous fibrosis
    Gupta S.
    Reddyand M.V.R.
    Harinath B.C.
    [J]. Indian Journal of Clinical Biochemistry, 2004, 19 (1) : 138 - 141
  • [6] Hemalatha A, 2006, Indian J Physiol Pharmacol, V50, P416
  • [7] Khanna R, 2005, Kathmandu Univ Med J (KUMJ), V3, P334
  • [8] Manoharan S, 2005, INDIAN J MED RES, V122, P529
  • [9] Paglia D. E., 1986, ANAL BIOCHEM, V16, P359
  • [10] Tobacco, Antioxidant Enzymes, Oxidative Stress, and Genetic Susceptibility in Oral Cancer
    Patel, Beena P.
    Rawal, Upendra M.
    Rawal, Rakesh M.
    Shukla, Shilin N.
    Patel, Prabhudas S.
    [J]. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2008, 31 (05): : 454 - 459
12