Association between fibroblast growth factor 7 and the risk of chronic obstructive pulmonary disease
被引:12
作者:
Xu, Si-cheng
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机构:Sichuan Univ, W China Hosp, Mol Med Res Ctr, Chengdu 610041, Peoples R China
Xu, Si-cheng
Kuang, Jiang-ying
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机构:Sichuan Univ, W China Hosp, Mol Med Res Ctr, Chengdu 610041, Peoples R China
Kuang, Jiang-ying
Liu, Jin
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机构:Sichuan Univ, W China Hosp, Mol Med Res Ctr, Chengdu 610041, Peoples R China
Liu, Jin
Ma, Chun-lan
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机构:Sichuan Univ, W China Hosp, Mol Med Res Ctr, Chengdu 610041, Peoples R China
Ma, Chun-lan
Feng, Yu-lin
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机构:Sichuan Univ, W China Hosp, Mol Med Res Ctr, Chengdu 610041, Peoples R China
Feng, Yu-lin
Su, Zhi-guang
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机构:
Sichuan Univ, W China Hosp, Mol Med Res Ctr, Chengdu 610041, Peoples R ChinaSichuan Univ, W China Hosp, Mol Med Res Ctr, Chengdu 610041, Peoples R China
Su, Zhi-guang
[1
]
机构:
[1] Sichuan Univ, W China Hosp, Mol Med Res Ctr, Chengdu 610041, Peoples R China
Aim: Fibroblast growth factor 7 (FGF7) is involved in a number of physiological and pathological processes, including lung disease. However, relatively little is known about the effect of FGF7 gene polymorphisms on chronic obstructive pulmonary disease (COPD) susceptibility. This study aimed to investigate the association between FGF7 polymorphisms with COPD susceptibility in a Chinese Han population. Methods: We conducted a case-control study of 279 COPD patients and 367 age-and gender-distribution-matched control subjects. The tagging SNPs rs10519225 and rs7170426 in FGF7 were genotyped by SNaPshot. The associations of each SNP genotype and haplotype constructed by these loci with COPD were analyzed. Results: A multivariate analysis showed that rs10519225 was significantly associated with an increased risk of COPD (P=0.011, OR=1.535, FDR q=0.022), whereas no association was found for rs7170426. Linkage disequilibrium (LD) analysis showed that these loci were in weak LD, with an r(2) of 0.033 and a D' of 0.232 (95% CI: 0.150-0.520). The haplotype constructed by allele G at rs10519225 and allele A at rs7170426 was associated with a decreased susceptibility to COPD (P=0.012, OR=0.751, FDR q=0.048). Conclusion: These findings suggest that FGF7 may be one susceptibility factor for COPD.
机构:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Wilk, Jemma B.
;
Chen, Ting-hsu
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h-index: 0
机构:
Boston Univ, Sch Med, Dept Med, Ctr Pulm, Boston, MA 02118 USA
NHLBI, Framingham Heart Study, Framingham, MA USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Chen, Ting-hsu
;
Gottlieb, Daniel J.
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h-index: 0
机构:
Boston Univ, Sch Med, Dept Med, Ctr Pulm, Boston, MA 02118 USA
NHLBI, Framingham Heart Study, Framingham, MA USA
Vet Affairs Boston Healthcare Syst, Boston, MA USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Gottlieb, Daniel J.
;
Walter, Robert E.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Dept Med, Ctr Pulm, Boston, MA 02118 USA
NHLBI, Framingham Heart Study, Framingham, MA USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Walter, Robert E.
;
Nagle, Michael W.
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h-index: 0
机构:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Nagle, Michael W.
;
Brandler, Brian J.
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h-index: 0
机构:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Brandler, Brian J.
;
Myers, Richard H.
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机构:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Myers, Richard H.
;
Borecki, Ingrid B.
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h-index: 0
机构:
Washington Univ, Sch Med, Div Stat Genom, St Louis, MO USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Borecki, Ingrid B.
;
Silverman, Edwin K.
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h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Lab, Boston, MA 02115 USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Silverman, Edwin K.
;
Weiss, Scott T.
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h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Lab, Boston, MA 02115 USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Weiss, Scott T.
;
O'Connor, George T.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Dept Med, Ctr Pulm, Boston, MA 02118 USA
NHLBI, Framingham Heart Study, Framingham, MA USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
机构:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Wilk, Jemma B.
;
Chen, Ting-hsu
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Dept Med, Ctr Pulm, Boston, MA 02118 USA
NHLBI, Framingham Heart Study, Framingham, MA USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Chen, Ting-hsu
;
Gottlieb, Daniel J.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Dept Med, Ctr Pulm, Boston, MA 02118 USA
NHLBI, Framingham Heart Study, Framingham, MA USA
Vet Affairs Boston Healthcare Syst, Boston, MA USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Gottlieb, Daniel J.
;
Walter, Robert E.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Dept Med, Ctr Pulm, Boston, MA 02118 USA
NHLBI, Framingham Heart Study, Framingham, MA USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Walter, Robert E.
;
Nagle, Michael W.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Nagle, Michael W.
;
Brandler, Brian J.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Brandler, Brian J.
;
Myers, Richard H.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Myers, Richard H.
;
Borecki, Ingrid B.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Div Stat Genom, St Louis, MO USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Borecki, Ingrid B.
;
Silverman, Edwin K.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Lab, Boston, MA 02115 USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Silverman, Edwin K.
;
Weiss, Scott T.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Lab, Boston, MA 02115 USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Weiss, Scott T.
;
O'Connor, George T.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Dept Med, Ctr Pulm, Boston, MA 02118 USA
NHLBI, Framingham Heart Study, Framingham, MA USABoston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA