Asymmetric hetero Diels-Alder reaction of N-benzylimines derived from R-glyceraldehyde: A new approach to homochiral piperidine building blocks and its application to the synthesis of (2R)-4-oxopipecolic acid

被引：34

作者：

Badorrey, R ^{[1
]}

Cativiela, C ^{[1
]}

DiazdeVillegas, MD ^{[1
]}

Galvez, JA ^{[1
]}

机构：

[1] UNIV ZARAGOZA, CSIC, INST CIENCIA MAT ARAGON, DEPT QUIM ORGAN, E-50009 ZARAGOZA, SPAIN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(97)00397-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The N-Benzyl imine derived from 23-di-O-benzyl-D-glyceraldehyde reacts with Danishefsky's diene to afford the corresponding hetero Diels-Alder adduct with a high diastereoselectivity. This compound can be transformed to enantiomerically pure (2R)-4-oxopipecolic acid. (C) 1997 Elsevier Science Ltd.

引用

页码：2547 / 2550

页数：4

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