Total Synthesis of Azithromycin

被引：34
作者：
Kim, Hyoung Cheul [1 ]
Kang, Sung Ho [1 ]
机构：
[1] Korea Adv Inst Sci & Technol, Dept Chem, Sch Mol Sci BK21, Taejon 305701, South Korea
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 10期
关键词：
asymmetric synthesis; desymmetrization; natural products; substituted glycerols; ASYMMETRIC TOTAL SYNTHESIS; ERYTHROMYCIN-A; ENANTIOSELECTIVE DESYMMETRIZATION; ALDEHYDES; ALCOHOLS; ADDITIONS; AZALIDES;
D O I：
10.1002/anie.200805334
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The quaternary king: Azithromycin (1), which has improved pharmacological profiles compared with erythromycins, was the target of an enantioselective synthesis. All the stereogenic quaternary carbon centers were elaborated by a desymmetrization of 2-substituted glycerols using a chiral imine/CuCl 2catalyst. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1827 / 1829
页数：3
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