Functional connectivity between the amygdala and prefrontal cortex in medication-naive individuals with major depressive disorder

被引:81
作者
Kong, Lingtao [1 ]
Chen, Kaiyuan [1 ]
Tang, Yanqing [1 ,2 ]
Wu, Feng [1 ]
Driesen, Naomi [3 ]
Womer, Fay [4 ]
Fan, Guoguang [2 ]
Ren, Ling [2 ]
Jiang, Wenyan [1 ]
Cao, Yang [5 ]
Blumberg, Hilary P. [3 ]
Xu, Ke [2 ]
Wang, Fei [2 ,3 ]
机构
[1] China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang 110001, Liaoning, Peoples R China
[2] China Med Univ, Affiliated Hosp 1, Dept Radiol, Shenyang 110001, Liaoning, Peoples R China
[3] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA
[4] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
[5] Mental Hlth Ctr Shenyang, Shenyang, Liaoning, Peoples R China
来源
JOURNAL OF PSYCHIATRY & NEUROSCIENCE | 2013年 / 38卷 / 06期
基金
中国国家自然科学基金;
关键词
MOOD-REGULATING CIRCUIT; ANTERIOR CINGULATE; EMOTIONAL FACES; FACIAL EXPRESSIONS; ASYMMETRY; ACTIVATION; ATTENTION; METAANALYSIS; DYSFUNCTION; PREDICTORS;
D O I
10.1503/jpn.120117
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Convergent evidence suggests dysfunction within the prefrontal cortex (PFC) and amygdala, important components of a neural system that subserves emotional processing, in individuals with major depressive disorder (MDD). Abnormalities in this system in the left hemisphere and during processing of negative emotional stimuli are especially implicated. In this study, we used functional magnetic resonance imaging (fMRI) to investigate amygdala-PFC functional connectivity during emotional face processing in medication-naive individuals with MDD. Methods: Individuals with MDD and healthy controls underwent fMRI scanning while processing 3 types of emotional face stimuli. We compared the strength of functional connectivity from the amygdala between the MDD and control groups. Results: Our study included 28 individuals with MDD and 30 controls. Decreased amygdala-left rostral PFC (rPFC) functional connectivity was observed in the MDD group compared with controls for the fear condition (p < 0.05, corrected). No significant differences were found in amygdala connectivity to any cerebral regions between the MDD and control groups for the happy or neutral conditions. Limitations: All participants with MDD were experiencing acute episodes, therefore the findings could not be generalized to the entire MDD population. Conclusion: Medication-naive individuals with MDD showed decreased amygdala-left rPFC functional connectivity in response to negative emotional stimuli, suggesting that abnormalities in amygdala-left rPFC neural circuitry responses to negative emotional stimuli might play an important role in the pathophysiology of MDD.
引用
收藏
页码:417 / 422
页数:6
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