Functional and phenotypic heterogeneity of group 3 innate lymphoid cells

被引：156

作者：

Melo-Gonzalez, Felipe ^{[1
]}

Hepworth, Matthew R. ^{[1
]}

机构：

[1] Univ Manchester, Fac Biol Med & Hlth, Sch Biol Sci, Div Infect Immun & Resp Med, Manchester, Lancs, England

来源：

IMMUNOLOGY | 2017年 / 150卷 / 03期

基金：

英国惠康基金;

关键词：

group 3 innate lymphoid cells; innate lymphoid cell; lymphoid tissue-inducer cells; mucosal immunology; ROR-GAMMA-T; ARYL-HYDROCARBON RECEPTOR; TRANSCRIPTION FACTOR GATA3; INTESTINAL INFLAMMATION; INDUCER CELLS; STEM-CELLS; TISSUE; NOTCH; GUT; DIFFERENTIATION;

D O I：

10.1111/imm.12697

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Group 3 innate lymphoid cells (ILC3), defined by expression of the transcription factor retinoid-related orphan receptor gamma t, play key roles in the regulation of inflammation and immunity in the gastrointestinal tract and associated lymphoid tissues. ILC3 consist largely of two major subsets, NCR+ ILC3 and LTi-like ILC3, but also demonstrate significant plasticity and heterogeneity. Recent advances have begun to dissect the relationship between ILC3 subsets and to define distinct functional states within the intestinal tissue microenvironment. In this review we discuss the ever-expanding roles of ILC3 in the context of intestinal homeostasis, infection and inflammation - with a focus on comparing and contrasting the relative contributions of ILC3 subsets.

引用

页码：265 / 275

页数：11

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