Vibsatins A and B, Two New Tetranorvibsane-Type Diterpenoids from Viburnum tinus cv. variegatus

被引：20

作者：

Gao, Xiu ^{[1
,2
]}

Shao, Li-Dong ^{[1
,2
]}

Dong, Liao-Bin ^{[1
,2
]}

Cheng, Xiao ^{[1
]}

Wu, Xing-De ^{[1
]}

Liu, Fei ^{[1
,2
]}

Jiang, Wei-Wei ^{[1
,2
]}

Peng, Li-Yan ^{[1
]}

He, Juan ^{[1
]}

Zhao, Qin-Shi ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 03期

关键词：

VIBSANE-TYPE DITERPENOIDS; BIOLOGICAL-ACTIVITIES; AWABUKI; ODORATISSIMUM; CYCLOADDITIONS; TRITERPENOIDS; CYLINDRICUM; CELLS;

D O I：

10.1021/ol403707a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Vibsatins A (1) and B (2), a pair of 14,15,16,17-tetranorvibsane-type diterpenoids that feature a bicyclo[4.2.1]nonane moiety formed by a new C-13/C-2 bond, were isolated from the twigs and leaves of Viburnum tin us cv. variegatus. The structures and absolute configurations were elucidated by a combination of NMR spectra, optical rotation, and X-ray diffraction experiments. A possible biogenetic pathway is also proposed. Moreover, vibsatin A (1) enhanced the neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 mu M.

引用

页码：980 / 983

页数：4

共 29 条

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