Interfacing carbon nanotubes with living cells

被引：236

作者：

Chen, Xing

Tam, Un Chong

Czlapinski, Jennifer L.

Lee, Goo Soo

Rabuka, David

Zettl, Alex ^{[1
]}

Bertozzi, Carolyn R.

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[5] Lawrence Berkeley Lab, Div Sci Mat, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 19期

关键词：

D O I：

10.1021/ja060276s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We developed a polymer coating for carbon nanotubes (CNTs) that mimics the mucin glycoprotein coating of mammalian cells. CNTs coated with these mucin mimic polymers have two novel properties: they can bind to carbohydrate receptors, providing a means for biomimetic interactions with cell surfaces, and, importantly, they are rendered nontoxic to cells. Copyright © 2006 American Chemical Society.

引用

收藏

页码：6292 / 6293

页数：2

相关论文

共 24 条

[1] Microtechnologies and nanotechnologies for single-cell analysis [J].

Andersson, H ;

van den Berg, A .

CURRENT OPINION IN BIOTECHNOLOGY, 2004, 15 (01) :44-49

[2] Near-infrared optical sensors based on single-walled carbon nanotubes [J].

Barone, PW ;

Baik, S ;

Heller, DA ;

Strano, MS .

NATURE MATERIALS, 2005, 4 (01) :86-U16

[3] Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors [J].

Chen, RJ ;

Bangsaruntip, S ;

Drouvalakis, KA ;

Kam, NWS ;

Shim, M ;

Li, YM ;

Kim, W ;

Utz, PJ ;

Dai, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :4984-4989

[4] Biomimetic engineering of carbon nanotubes by using cell surface mucin mimics [J].

Chen, X ;

Lee, GS ;

Zettl, A ;

Bertozzi, CR .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (45) :6111-6116

[5] Near-infrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cells [J].

Cherukuri, P ;

Bachilo, SM ;

Litovsky, SH ;

Weisman, RB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (48) :15638-15639

[6] Cell surface biology mediated by low affinity multivalent protein-glycan interactions [J].

Collins, BE ;

Paulson, JC .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2004, 8 (06) :617-625

[7] Effect of single wall carbon nanotubes on human HEK293 cells [J].

Cui, DX ;

Tian, FR ;

Ozkan, CS ;

Wang, M ;

Gao, HJ .

TOXICOLOGY LETTERS, 2005, 155 (01) :73-85

[8] Intracellular functions of N-linked glycans [J].

Helenius, A ;

Aebi, M .

SCIENCE, 2001, 291 (5512) :2364-2369

[9] Mucins in cancer: Protection and control of the cell surface [J].

Hollingsworth, MA ;

Swanson, BJ .

NATURE REVIEWS CANCER, 2004, 4 (01) :45-60

[10] Cytotoxicity of carbon nanomaterials: Single-wall nanotube, multi-wall nanotube, and fullerene [J].

Jia, G ;

Wang, HF ;

Yan, L ;

Wang, X ;

Pei, RJ ;

Yan, T ;

Zhao, YL ;

Guo, XB .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2005, 39 (05) :1378-1383