Mechanisms of action of intravenous immunoglobulin

被引：94

作者：

Chaigne, Benjamin ^{[1
,2
]}

Mouthon, Luc ^{[1
,2
]}

机构：

[1] Univ Paris 05, Hop Cochin, Assistance Publ Hopitaux Paris,Serv Med Interne, Fac Med,Ctr Reference Vascularites Necrosantes &, Paris, France

[2] Univ Paris 05, CNRS UMR 8104, INSERM U1016, Inst Cochin, Paris, France

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2017年 / 56卷 / 01期

关键词：

Intravenous immunoglobulins; Substitution; Immunomodulation; Auto-immune diseases; REGULATORY T-CELLS; HUMAN DENDRITIC CELLS; ANTIINFLAMMATORY ACTIVITY; B-CELLS; AUTOIMMUNE-DISEASES; IN-VITRO; RECEPTOR; SIALYLATION; DERMATOMYOSITIS; INHIBITION;

D O I：

10.1016/j.transci.2016.12.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Taking advantage of the "World Apheresis Association/Societe Francaise d'Hemapherese" meeting held in Paris in April 2016, this article reviews the current knowledge on the mechanisms of action of intravenous immunoglobulins. Immunoglobulins are a plasma-derived drug, which have been initially used as a replacement therapy for patients with antibody deficiency. Since 1980 they have also been used for their anti-inflammatory and immunomodulating efficacy in auto-immune diseases. Herein, we review the requirements for their production and composition before giving a specific attention to their mechanisms of action including substitution and immunomodulation. (c) 2017 Elsevier Ltd. All rights reserved.

引用

页码：45 / 49

页数：5

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