Prognostic implications of changes in cardiac troponin I levels in patients with non-ST elevation acute coronary syndrome

被引：6

作者：

Eggers, Kai M. ^{[1
]}

James, Stefan ^{[1
]}

Venge, Per ^{[1
]}

Lindahl, Bertil ^{[2
]}

机构：

[1] Uppsala Univ, Fac Med, Dept Med Sci, Cardiol Unit, S-75185 Uppsala, Sweden

[2] Uppsala Univ, Uppsala Clin Res Ctr, S-75185 Uppsala, Sweden

来源：

BIOMARKERS | 2013年 / 18卷 / 08期

关键词：

Acute coronary syndrome; cardiac troponin I; cardiovascular events; risk prediction; INFARCT SIZE; MYOCARDIAL-INFARCTION; UNSTABLE ANGINA; INTERVENTION; ABCIXIMAB; ABSOLUTE; SERIAL; TRIAL;

D O I：

10.3109/1354750X.2013.843023

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: Information is limited on the prognostic implications of cardiac troponin I (cTnI) changes during the first days of non-ST elevation acute coronary syndrome (NSTE-ACS). Methods: High-sensitivity cTnI levels were measured at study inclusion and after 48 h in 1615 conservatively managed NSTE-ACS patients from the Global Use of Strategies To Open Occluded Coronary Arteries (GUSTO) IV trial. Results: Patients with moderately increased cTnI levels and without a relevant decrease over time had a significantly raised mortality at 30 days and 1 year. No relevant associations between cTnI changes and recurrent myocardial infarction were seen. Conclusion: The cTnI change is predictive for subsequent mortality in selected conservatively managed NSTE-ACS patients.

引用

页码：668 / 672

页数：5

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