Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology

被引：99

作者：

Tsai, Tsung-Han ^{[1
,2
]}

Potsaid, Benjamin ^{[1
,2
,3
]}

Tao, Yuankai K. ^{[1
,2
]}

Jayaraman, Vijaysekhar ^{[4
]}

Jiang, James ^{[3
]}

Heim, Peter J. S. ^{[5
]}

Kraus, Martin F. ^{[1
,2
,6
,7
]}

Zhou, Chao ^{[1
,2
]}

Hornegger, Joachim ^{[6
,7
]}

Mashimo, Hiroshi ^{[8
,9
]}

Cable, Alex E. ^{[3
]}

Fujimoto, James G. ^{[1
,2
]}

机构：

[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[2] MIT, Elect Res Lab, Cambridge, MA 02139 USA

[3] Thorlabs Inc, Adv Imaging Grp, Newton, NJ USA

[4] Praevium Res Inc, Santa Barbara, CA USA

[5] Thorlabs Quantum Elect Inc, Jessup, MD USA

[6] Univ Erlangen Nurnberg, Pattern Recognit Lab, Nurnberg, Germany

[7] Univ Erlangen Nurnberg, Grad Sch Adv Opt Technol, Nurnberg, Germany

[8] Vet Affairs Healthcare Syst Boston, Boston, MA USA

[9] Harvard Univ, Sch Med, Boston, MA USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2013年 / 4卷 / 07期

基金：

美国国家卫生研究院;

关键词：

FREQUENCY-DOMAIN REFLECTOMETRY; IN-VIVO; SWEPT-SOURCE; MODE-LOCKING; OCT; LASER; MICROSCOPY; SCANS;

D O I：

10.1364/BOE.4.001119

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We developed a micromotor based miniature catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surface-emitting laser (VCSEL) at a 1 MHz axial scan rate. The micromotor can rotate a micro-prism at several hundred frames per second with less than 5 V drive voltage to provide fast and stable scanning, which is not sensitive to the bending of the catheter. The side-viewing probe can be pulled back to acquire a three-dimensional (3D) data set covering a large area on the specimen. The VCSEL provides a high axial scan rate to support dense sampling under high frame rate operation. Using a high speed data acquisition system, in vivo 3D-OCT imaging in the rabbit GI tract and ex vivo imaging of a human colon specimen with 8 mu m axial resolution, 8 mu m lateral resolution and 1.2 mm depth range in tissue at a frame rate of 400 fps was demonstrated. (C) 2013 Optical Society of America

引用

页码：1119 / 1132

页数：14

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