Association between polymorphisms of folate-metabolizing enzymes and hematological malignancies

被引：63

作者：

Kim, Hee Nam ^{[2
]}

Kim, Yeo-Kyeoung ^{[1
]}

Lee, Il-Kwon ^{[2
]}

Yang, Deok-Hwan ^{[1
]}

Lee, Je-Jung ^{[1
]}

Shin, Min-Ho ^{[3
]}

Park, Kyeong-Soo ^{[4
]}

Choi, Jin-Su ^{[3
]}

Park, Moo Rim ^{[5
]}

Jo, Deog Yeon ^{[6
]}

Won, Jong Ho ^{[7
]}

Kwak, Jae-Yong ^{[8
]}

Kim, Hyeoung-Joon ^{[1
,2
]}

机构：

[1] Chonnam Natl Univ, Hwasun Hosp, Dept Hematol Oncol, Hwasun Gun 519809, Jeollanam Do, South Korea

[2] Chonnam Natl Univ, Hwasun Hosp, Genome Res Ctr Hematopoiet Dis, Hwasun Gun 519809, Jeollanam Do, South Korea

[3] Chonnam Natl Univ, Sch Med, Dept Prevent Med, Kwangju, South Korea

[4] Seonam Univ, Coll Med, Dept Prevent Med, Namwon, South Korea

[5] Wonkwang Univ, Sch Med, Dept Internal Med, Iksan, South Korea

[6] Chungnam Natl Univ, Coll Med, Dept Internal Med, Div Hematol Oncol, Taejon, South Korea

[7] Soonchunhyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[8] Chonbuk Natl Univ, Sch Med, Dept Internal Med, Jeonju, South Korea

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 01期

关键词：

AML; CML; MDS; ALL; Polymorphism; Folate-metabolizing enzymes; Association; ACUTE LYMPHOBLASTIC-LEUKEMIA; NON-HODGKIN-LYMPHOMA; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; METHIONINE SYNTHASE REDUCTASE; CHRONIC MYELOGENOUS LEUKEMIA; ACUTE LYMPHOCYTIC-LEUKEMIA; THYMIDYLATE-SYNTHASE; COLORECTAL ADENOMAS; COMMON MUTATION; MESSENGER-RNA;

D O I：

10.1016/j.leukres.2008.07.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several genetic polymorphisms in the genes coding folate-metabolizing enzymes have been associated with susceptibility to hematology malignancies. We conducted a Korean population-based case-control study to examine the relationship between the polymorphisms of folate-metabolizing enzymes and the risk of AML (acute myelogenous leukemia), CML (chronic myelogenous leukemia), MDS (myelodyspastic syndrome), and ALL (acute lymphoblastc leukemia). The MTHFR 677TT genotype was associated with an increased risk for ALL (odds ratios (OR) = 1.77; 95% confidence intervals (CI) = 1.02-3.09, p = .044). The MTRR 66 AG genotype was associated with an increased risk for MDS (OR = 1.59; 1.06-2.38, p = .026) and the MTRR 66 GG genotype was associated with increased risk for AML (OR = 1.51; 1.03-2.23, p = .037). The TYMS 2R3R genotype was associated with a decreased risk for AML (OR = 0.76; 0.60-0.96, p = .022). The TYMS hap3 (2R-6bp) and hap4 (2R-Obp) were associated with decreased risk (OR = 0.69; 0.53-0.90, p = .006) and increased risk (OR = 1.65; 1.20-2.27, p = .002), respectively for AML. Hap C (677T-1298A) was associated with an increased risk (OR = 1.40; 1.02-1.92, p = .04) for ALL. The risk for ALL appears to be associated with the MTHFR 677 polymorphism. The results are supportive of a risk modification by folate polymorphisms in several hematologic malignancies in Korea. The pattern of results suggests that MDS was associated with the DNA methylation status and the risk for AML was associated with both the DNA synthesis and DNA methylation status. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：82 / 87

页数：6

共 37 条

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