The existence and function of mitochondrial component in extracellular vesicles

被引：38

作者：

Liu, Dan ^{[2
]}

Dong, Zhanchen ^{[1
]}

Wang, Jinling ^{[1
]}

Tao, Ye ^{[1
]}

Sun, Xiance ^{[1
]}

Yao, Xiaofeng ^{[1
]}

机构：

[1] Dalian Med Univ, Dept Prevent Med, 9 W Lushun South Rd, Dalian 116044, Peoples R China

[2] Dalian Med Univ, Dept Endocrinol, Affiliated Hosp 1, 222 Zhongshan Rd, Dalian 116011, Peoples R China

来源：

MITOCHONDRION | 2020年 / 54卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Mitochondrial transfer; Extracellular vesicles; Microvesicles; Exosomes; Mitochondrial components; CELLS; DNA; MICROVESICLES; RELEASE; ASTROCYTES; REGULATORS; TRANSPORT; MEMBRANE; EXOSOMES; NEURONS;

D O I：

10.1016/j.mito.2020.08.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Intercellular transfer of mitochondria and mitochondrial components through extracellular vesicles (EVs), including microvesicles and exosomes, is an area of intense interest. The cargos that are carried by EVs define their biological activities. Mitochondria are in charge of bioenergetics and maintenance of cell viability. Increasing evidences indicate the presence of intact mitochondria or mitochondrial components in EVs, which raises many questions, how they are engulfed into EVs and what do they do? Here, we present what is currently known about the presence and function of various mitochondrial constituent in EVs. We also review current understanding about how and why mitochondrial components are encapsulated into EVs.

引用

页码：122 / 127

页数：6

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